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1. (WO2008055959) NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2008/055959 International Application No.: PCT/EP2007/062085
Publication Date: 15.05.2008 International Filing Date: 08.11.2007
IPC:
C07D 487/04 (2006.01) ,A61K 31/519 (2006.01) ,A61P 19/02 (2006.01) ,A61P 19/10 (2006.01) ,A61P 29/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
02
for joint disorders, e.g. arthritis, arthrosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
08
for bone diseases, e.g. rachitism, Paget's disease
10
for osteoporosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
Applicants:
EDWARDS, Paul [GB/CA]; CA (UsOnly)
CHAMBERS, Mark Stuart [GB/GB]; GB (UsOnly)
MENET, Christel Jeanne Marie [FR/BE]; BE (UsOnly)
FLETCHER, Stephen Robert [GB/BE]; BE (UsOnly)
JARVIS, Rebecca Elizabeth [GB/GB]; GB (UsOnly)
VAN DE POËL, Hervé [FR/GB]; GB (UsOnly)
SUDAU, Alexander [DE/DE]; DE (UsOnly)
RAE, Alastair [GB/GB]; GB (UsOnly)
THOMAS, Peter Stanley [GB/GB]; GB (UsOnly)
GALAPAGOS N.V. [BE/BE]; Generaal De Wittelaan L11/A3 B-2800 Mechelen, BE (AllExceptUS)
Inventors:
EDWARDS, Paul; CA
CHAMBERS, Mark Stuart; GB
MENET, Christel Jeanne Marie; BE
FLETCHER, Stephen Robert; BE
JARVIS, Rebecca Elizabeth; GB
VAN DE POËL, Hervé; GB
SUDAU, Alexander; DE
RAE, Alastair; GB
THOMAS, Peter Stanley; GB
Agent:
NICHOL, Maria; Galapagos NV Chesterford Research Park Little Chesterford Saffron Walden Essex CB10 1XL, GB
Priority Data:
60/865,03109.11.2006US
Title (EN) NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES
(FR) NOUVEAUX COMPOSÉS UTILISÉS DANS LE TRAITEMENT DE MALADIES DÉGÉNÉRATIVES ET INFLAMMATOIRES
Abstract:
(EN) The present invention relates to compounds of formula (I) that are inhibitors of PDElA, a phosphodiesterase that is involved in the modulation of the degradation of cartilage, joint degeneration and diseases involving such degradation and/or inflammation.
(FR) La présente invention concerne des composés représentés par la formule (I), qui sont des inhibiteurs de PDElA, une phosphodiestérase associée à la modulation de la dégradation du cartilage, la dégénération des articulations et les maladies associées à une telle dégradation et/ou inflammation.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)