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1. WO2008054603 - IL-17 RECEPTOR A ANTIGEN BINDING PROTEINS

Publication Number WO/2008/054603
Publication Date 08.05.2008
International Application No. PCT/US2007/021174
International Filing Date 01.10.2007
IPC
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61P 37/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61K 2039/507
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
507Comprising a combination of two or more separate antibodies
A61K 39/3955
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
39533against materials from animals
3955against proteinaceous materials, e.g. enzymes, hormones, lymphokines
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Applicants
  • AMGEN INC. [US]/[US] (AllExceptUS)
  • TOCKER, Joel [US]/[US] (UsOnly)
  • PESCHON, Jacques, J. [US]/[US] (UsOnly)
  • FITZPATRICK, David [AU]/[US] (UsOnly)
  • SMOTHERS, James, F. [US]/[US] (UsOnly)
  • MEHLIN, Christopher [US]/[US] (UsOnly)
  • LIM, Ai Ching [US]/[US] (UsOnly)
Inventors
  • TOCKER, Joel
  • PESCHON, Jacques, J.
  • FITZPATRICK, David
  • SMOTHERS, James, F.
  • MEHLIN, Christopher
  • LIM, Ai Ching
Agents
  • KLANIECKI, James E.
Priority Data
60/827,88202.10.2006US
60/873,07205.12.2006US
60/969,89504.09.2007US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) IL-17 RECEPTOR A ANTIGEN BINDING PROTEINS
(FR) PROTÉINES DE LIAISON À L'ANTIGÈNE DU RÉCEPTEUR A DE L'IL-17
Abstract
(EN)
The present invention relates to IL-17 Receptor A (IL-17RA or IL-17R) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases mediated by IL-17 Receptor A activation by one or more IL-17 ligands. The present invention relates to the identification of neutralizing determinants on IL-17 Receptor A (IL-17RA or IL-17R) and antibodies that bind thereto. Aspects of the invention also include antibodies that compete for binding with the IL-17RA neutralizing antibodies described herein.
(FR)
La présente invention concerne des protéines de liaison à l'antigène du récepteur A de l'IL-17 (IL-17RA ou IL-17R) telles que des anticorps, des séquences polynucléotidiques codant pour lesdites protéines de liaison à l'antigène, ainsi que des compositions et des procédés de diagnostic et de traitement de maladies induites par l'activation du récepteur A de l'IL-17 par un ou plusieurs ligands de l'IL-17. La présente invention concerne l'identification de déterminants neutralisants sur le récepteur A de l'IL-17 (IL-17RA ou IL-17R) et des anticorps qui se lient à eux. L'invention concerne également des anticorps qui entrent en compétition pour la liaison avec les anticorps neutralisants de l'IL-17RA décrits ici.
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