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1. (WO2008052138) INLINE-INJECTION MICRODEVICE AND MICROFABRICATED INTEGRATED DNA ANALYSIS SYSTEM USING SAME
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2008/052138 International Application No.: PCT/US2007/082568
Publication Date: 02.05.2008 International Filing Date: 25.10.2007
IPC:
C12M 1/00 (2006.01) ,B01J 10/00 (2006.01) ,B01L 99/00 (2010.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1
Apparatus for enzymology or microbiology
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
J
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS, COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
10
Chemical processes in general for reacting liquid with gaseous media other than in the presence of solid particles, or apparatus specially adapted therefor
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
L
CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
99
Subject matter not provided for in other groups of this subclass
Applicants:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, 12th Floor Oakland, California 94607-5200, US (AllExceptUS)
MATHIES, Richard, A. [US/US]; US (UsOnly)
BLAZEJ, Robert, G. [US/US]; US (UsOnly)
KUMARESAN, Palani [IN/US]; US (UsOnly)
Inventors:
MATHIES, Richard, A.; US
BLAZEJ, Robert, G.; US
KUMARESAN, Palani; US
Agent:
BERGIN, Denise, S. ; BEYER WEAVER LLP P.O. Box 70250 Oakland, California 94612-0250, US
Priority Data:
60/854,57025.10.2006US
60/881,41119.01.2007US
Title (EN) INLINE-INJECTION MICRODEVICE AND MICROFABRICATED INTEGRATED DNA ANALYSIS SYSTEM USING SAME
(FR) MICRODISPOSITIF À INJECTION EN LIGNE ET SYSTÈME D'ANALYSE D'ADN INTÉGRÉ MICRO-USINÉ FAISANT INTERVENIR CE MICRODISPOSITIF
Abstract:
(EN) Methods and microfluidic circuitry for inline injection of nucleic acids for capillary electrophoresis analysis are provided. According to various embodiments, microfabricated structures including affinity-based capture matrixes inline with separation channels are provided. The affinity-based capture matrixes provide inline sample plug formation and injection into a capillary electrophoresis channel. Also provided are methods and apparatuses for a microbead-based inline injection system for DNA sequencing.
(FR) L'invention concerne des procédés et une circuiterie microfluidique permettant une injection en ligne d'acides nucléiques destinée à une analyse d'électrophorèse capillaire. Selon des modes de réalisations variés de l'invention, des structures micro-usinées comprennent des matrices de capture fondées sur les affinités alignées avec des canaux de séparation. Les matrices de capture fondées sur les affinités permettent d'obtenir une formation de bouchon d'échantillon en ligne et une injection dans un canal d'électrophorèse capillaire. L'invention concerne également des procédés et des appareils destinés à un système d'injection en ligne fondé sur des microbilles destiné à un séquençage d'ADN.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)