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1. WO2008051285 - METHODS AND COMPOSITIONS FOR DETECTING FUNGI AND MYCOTOXINS

Publication Number WO/2008/051285
Publication Date 02.05.2008
International Application No. PCT/US2007/008249
International Filing Date 30.03.2007
IPC
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
02
with ribosyl as saccharide radical
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04
with deoxyribosyl as saccharide radical
C12Q 1/68 (2006.01)
C07H 21/02 (2006.01)
C07H 21/04 (2006.01)
CPC
C12Q 1/6895
C12Q 2600/142
G01N 2469/10
G01N 2800/26
G01N 2800/50
G01N 33/56961
Applicants
  • MEDICAL SERVICE CONSULTATION INTERNATIONAL, LLC [US/US]; 8325 Walnut Hill Lane, Suite 125 Dallas, TX 75231, US (AllExceptUS)
  • HOOPER, Dennis, G. [US/US]; US (UsOnly)
Inventors
  • HOOPER, Dennis, G.; US
Agents
  • BALL, Rebecca, L.; Barnes & Thornburg LLP 11 South Meridian Street Indianapolis, IN 46204, US
Priority Data
60/787,75401.04.2006US
60/790,97411.04.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND COMPOSITIONS FOR DETECTING FUNGI AND MYCOTOXINS
(FR) PROCÉDÉS ET COMPOSITIONS DE DÉTECTION DE CHAMPIGNONS ET DE MYCOTOXINES
Abstract
(EN)
The invention relates to a method of identifying a specific fungal species in patient tissue or body fluid. The method comprises the steps of extracting and recovering DNA of the fungal species from the patient tissue or body fluid, amplifying the DNA, hybridizing a probe to the DNA to specifically identify the fungal species, and specifically identifying the fungal species. The invention also relates to a method of identifying a mycotoxin in patient tissue or body fluid. The method comprises the steps of extracting and recovering the mycotoxin from the patient tissue or body fluid, contacting the mycotoxin with an antibody directed against the mycotoxin, and identifying the myocotoxin. Both of these methods can be used to determine if a patient is at risk for or has developed a disease state related to a fungal infection, and to develop an effective treatment regimen for the patient.
(FR)
La présente invention concerne un procédé d'identification d'espèces fongiques dans le tissu ou le liquide organique d'un patient. Le procédé comprend les étapes suivantes : l'extraction et la récupération d'ADN d'espèces fongiques à partir du tissu ou liquide organique du patient, l'amplification de l'ADN, l'hybridation d'une sonde à l'ADN pour l'identification spécifique des espèces fongiques, et l'identification spécifique des espèces fongiques. L'invention concerne également un procédé d''identification d'une mycotoxine dans le tissu ou liquide organique d'un patient. Le procédé comprend l'extraction et la récupération de la mycotoxine du tissu ou liquide organique du patient, la mise en contact de la mycotoxine avec un anticorps dirigé contre la mycotoxine, et l'identification de la mycotoxine. Les deux procédés peuvent être utilisés pour déterminer si un patient est à risque de développer ou a développé un état morbide associé à une infection d'origine fongique, et pour développer un régime de traitement efficace pour le patient.
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