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1. (WO2008048545) MOLECULES WITH REDUCED HALF-LIVES, COMPOSITIONS AND USES THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2008/048545 International Application No.: PCT/US2007/021991
Publication Date: 24.04.2008 International Filing Date: 16.10.2007
IPC:
C12P 21/08 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21
Preparation of peptides or proteins
08
Monoclonal antibodies
Applicants:
MEDIMMUNE, LLC. [US/US]; One Medimmune Way Gaithersburg, MD 20878, US (AllExceptUS)
DALL'ACQUA, William [FR/US]; US (UsOnly)
WU, Herren [US/US]; US (UsOnly)
Inventors:
DALL'ACQUA, William; US
WU, Herren; US
Agent:
HOLMES-SON, Michelle ; Medimmune, Inc. One Medimmune Way Gaithersburg, MD 20878, US
Priority Data:
60/851,73916.10.2006US
Title (EN) MOLECULES WITH REDUCED HALF-LIVES, COMPOSITIONS AND USES THEREOF
(FR) MOLÉCULES AYANT DES DEMI-VIES RÉDUITES, COMPOSITIONS ET LEURS UTILISATIONS
Abstract:
(EN) The present invention provides polypeptides containing at least the FcRn binding portion of an Fc region of an immunoglobulin molecule and that have altered amino acid sequences relative to wild type immunoglobulin molecules. The polypeptides have decreased in vivo serum half-lives and can be employed in various methods.
(FR) L'invention concerne des polypeptides qui contiennent au moins la partie de liaison de FcRn d'une zone Fc d'une molécule d'immunoglobuline, et qui possèdent des séquences d'acides aminés modifiées par rapport à des molécules d'immunoglobuline de type sauvage. Les polypeptides ont des demi-vies sériques in vivo réduites et peuvent être utilisés dans divers procédés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2064335JP2010506842EP2407548US20100143254CA2665826AU2007313300