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1. WO2008048209 - FUNCTIONALIZATION OF NANOFLUIDIC CHANNELS

Publication Number WO/2008/048209
Publication Date 24.04.2008
International Application No. PCT/US2006/026318
International Filing Date 06.07.2006
Chapter 2 Demand Filed 27.11.2006
IPC
C12M 1/34 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
34Measuring or testing with condition measuring or sensing means, e.g. colony counters
CPC
G01N 33/54373
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
54366Apparatus specially adapted for solid-phase testing
54373involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
Applicants
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US]/[US] (AllExceptUS)
  • YANG, Peidong [CN]/[US] (UsOnly)
  • KARNIK, Rohit [IN]/[US] (UsOnly)
  • CASTELINO, Kenneth [IN]/[US] (UsOnly)
  • FAN, Rong [CH]/[US] (UsOnly)
  • MANJUMDAR, Arun [US]/[US] (UsOnly)
Inventors
  • YANG, Peidong
  • KARNIK, Rohit
  • CASTELINO, Kenneth
  • FAN, Rong
  • MANJUMDAR, Arun
Agents
  • O'BANION, John, P.
Priority Data
60/697,33206.07.2005US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) FUNCTIONALIZATION OF NANOFLUIDIC CHANNELS
(FR) FONCTIONNALISATION DE CANAUX NANOFLUIDIQUES
Abstract
(EN)
A functionalized nanofluidic channel and method for functionalization that provides control over the ionic environment and geometry of the nanofluidic channel with the immobilization of biomolecules on the inner surface of the channel and use of high ionic concentration solutions. In one embodiment, the surface charge of the nanochannel is controlled with the immobilization of a protein such as streptavidin in the nanochannel. In another embodiment, the biomolecules are receptors and changes in nanochannel conductance indicates ligand binding events. The functionalized nanofluidic channel can be easily adapted for use with microchannel arrays.
(FR)
L'invention concerne un canal nanofluidique fonctionnalisé et un procédé de fonctionnalisation permettant de contrôler l'environnement ionique et la géométrie dudit canal via l'immobilisation de biomolécules sur la surface intérieure du canal et l'utilisation de solutions à concentrations ioniques élevées. Selon un mode de réalisation, la charge de surface du nanocanal est contrôlée via l'immobilisation d'une protéine telle que la streptavidine dans le nanocanal. Selon un autre mode de réalisation, les biomolécules sont des récepteurs et les changements de conductance des nanocanaux indiquent des événements de liaison avec des ligands. Le canal nanofluidique fonctionnalisé de l'invention peut être facilement adapté pour être utilisé dans des réseaux de nanocanaux.
Also published as
EP06851657
EP6851657
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