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1. WO2008042806 - STILBENEDISULFONIC ACID DERIVATIVES AS INHIBITORS OF RETROVIRAL INTEGRASE

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Publication Number WO/2008/042806
Publication Date 10.04.2008
International Application No. PCT/US2007/079980
International Filing Date 28.09.2007
IPC
A61K 31/185 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
A61P 31/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
A61P 31/18 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
18for HIV
G01N 33/50 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
CPC
A61K 31/185
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
A61P 31/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
18for HIV
G01N 2333/16
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
005from viruses
08RNA viruses
15Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
155Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
16HIV-1, HIV-2
G01N 33/56988
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
56983Viruses
56988AIDS or HTLV
Applicants
  • THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES [US]/[US] (AllExceptUS)
  • POMMIER, Yves [US]/[US] (UsOnly)
  • SEMENOVA, Elena [RU]/[US] (UsOnly)
  • MARCHAND, Christophe [FR]/[US] (UsOnly)
Inventors
  • POMMIER, Yves
  • SEMENOVA, Elena
  • MARCHAND, Christophe
Agents
  • GAO, Chuan
Priority Data
60/849,71804.10.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) STILBENEDISULFONIC ACID DERIVATIVES AS INHIBITORS OF RETROVIRAL INTEGRASE
(FR) DÉRIVÉS D'ACIDE STILBÈNEDISULFONIQUE COMME INHIBITEURS DE L'INTÉGRASE RÉTROVIRALE
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Abstract
(EN)
The present invention provides a class of novel stilbenedisulfonic acid derivatives. These compounds have the activity as inhibitors of retroviral integrase, an essential enzyme for the proliferation of retroviruses such as HIV-1. Also described in this application are pharmaceutical compositions comprising at least one of the stilbenedisulfonic acid derivatives and a method of using the stilbenedisulfonic acid derivatives to inhibit retroviral proliferation. In addition, this application provides a new method for identifying compounds that inhibits retrovirus integrase activity.
(FR)
La présente invention concerne une classe de nouveaux dérivés d'acide stilbènedisulfonique. Ces composés ont une activité d'inhibiteurs de l'intégrase rétrovirale, une enzyme essentielle pour la prolifération de rétrovirus tels que le VIH-1. L'invention décrit également des compositions pharmaceutiques comportant au moins un des dérivés d'acide stilbènedisulfonique et un procédé d'utilisation des dérivés d'acide stilbènedisulfonique pour empêcher une prolifération rétrovirale. De plus, l'invention fournit un nouveau procédé pour identifier des composés qui empêchent l'activité d'une intégrase de rétrovirus.
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