Processing

Please wait...

Settings

Settings

Goto Application

1. WO2008040027 - DIRECTED DIFFERENTIATION AND MATURATION OF STEM CELL-DERIVED CARDIOMYOCYTES

Publication Number WO/2008/040027
Publication Date 03.04.2008
International Application No. PCT/US2007/080013
International Filing Date 28.09.2007
IPC
C12N 5/00 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
C12N 15/00 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
CPC
A61K 35/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
C07K 14/705
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C12N 2501/235
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2501Active agents used in cell culture processes, e.g. differentation
20Cytokines; Chemokines
23Interleukins [IL]
235Leukemia inhibitory factor [LIF]
C12N 2501/998
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2501Active agents used in cell culture processes, e.g. differentation
998Proteins not provided for elsewhere
C12N 2502/13
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2502Coculture with; Conditioned medium produced by
13connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
Applicants
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US]/[US] (AllExceptUS)
  • LI, Ronald [CA]/[US] (UsOnly)
  • SIU, David Cw [CN]/[US] (UsOnly)
Inventors
  • LI, Ronald
  • SIU, David Cw
Agents
  • KONSKI, Antoinette F.
Priority Data
60/848,11428.09.2006US
60/848,15928.09.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DIRECTED DIFFERENTIATION AND MATURATION OF STEM CELL-DERIVED CARDIOMYOCYTES
(FR) DIFFÉRENCIATION ET MATURATION DIRIGÉES DE CARDIOMYOCYTES DÉRIVÉS D'UNE CELLULE SOUCHE
Abstract
(EN)
This invention provides an isolated electrophysiologically immature cell or its derivative that has been modified to provide a mature electrophysiological phenotype and populations of these cells. Compositions containing these cells and populations of cells are also provided by this invention. These cells and compositions have therapeutic and diagnostic uses. Non-limiting therapeutic uses include regenerating cardiac tissue, improving cardiac function, restoring action potential of cardiac tissue; and treating or preventing cardiac malfunction. The cells and population of cells also can be used diagnostically to screen drug or other therapeutic candidate.
(FR)
L'invention fournit une cellule isolée électrophysiologiquement immature ou sa dérivée modifiée pour fournir un phénotype électrophysiologique mature et des populations de ces cellules. Des compositions contenant ces cellules et des populations de cellules sont aussi fournies par l'invention. Les cellules et les compositions ont des utilisations thérapeutiques et diagnostiques. Les utilisations thérapeutiques non limitatrices comprennent la régénération d'un tissu cardiaque, l'amélioration d'une fonction cardiaque, la restauration d'un potentiel d'action d'un tissu cardiaque et le traitement ou la prévention d'un mauvais fonctionnement cardiaque. Les cellules et les populations de cellules peuvent aussi être utilisées dans un diagnostic pour cribler un médicament ou un autre élément thérapeutique.
Also published as
Latest bibliographic data on file with the International Bureau