Search International and National Patent Collections

1. (WO2008032164) BENZIMIDAZOLONE DERIVATIVES

Pub. No.:    WO/2008/032164    International Application No.:    PCT/IB2007/002583
Publication Date: Fri Mar 21 00:59:59 CET 2008 International Filing Date: Tue Sep 04 01:59:59 CEST 2007
IPC: C07D 235/26
A61K 31/16
Applicants: PFIZER PRODUCTS INC.
ANDO, Kazuo
BUCHLER, Ingrid, Price
HEDGE, Shridhar Gajanan
KAWAI, Makoto
MASUDA, Tsutomu
OMURA, Hirofumi
Inventors: ANDO, Kazuo
BUCHLER, Ingrid, Price
HEDGE, Shridhar Gajanan
KAWAI, Makoto
MASUDA, Tsutomu
OMURA, Hirofumi
Title: BENZIMIDAZOLONE DERIVATIVES
Abstract:
This invention relates to compounds and methods for the treatment of a condition mediated by CB1 receptor activity in a mammalian subject including a human, which comprises administering to a mammal in need of such treatment a therapeutically effective amount of the compound of formula (I) or pharmaceutically acceptable salts thereof, wherein: A, B, R1, R2 and R3 are each as described herein. These compounds are useful in the treatment of a condition mediated by CB2 receptor binding activity such as, but not limited to, inflammatory pain, nociceptive pain, neuropathic pain, fibromyalgia, chronic low back pain, visceral pain, acute cerebral ischemia, pain, chronic pain, acute pain, post herpetic neuralgia, neuropathies, neuralgia, diabetic neuropathy, HIV-related neuropathy, nerve injury, rheumatoid arthritic pain, osteoarthritic pain, back pain, cancer pain, dental pain, fibromyalgia, neuritis, sciatica, inflammation, neurodegenerative disease, spasticity, epilepsy, Tourette's syndrome, Parkinson's disease, neuroprotection, anxiety, cough, broncho constriction, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), colitis, cerebrovascular ischemia, cachexia, nausea, emesis, chemotherapy-induced emesis, rheumatoid arthritis, asthma, Crohn's disease, ulcerative colitis, asthma, dermatitis, seasonal allergic rhinitis, gastroesophageal reflux disease (GERD), constipation, diarrhea, functional gastrointestinal disorder, cutaneous T cell lymphoma, multiple sclerosis, osteoarthritis, psoriasis, systemic lupus erythematosus, diabetes, glaucoma, osteoporosis, glomerulonephritis, renal ischemia, nephritis, hepatitis, cerebral stroke, vasodialation, hypertension, vasculitis, myocardial infarction, cerebral ischemia, reversible airway obstruction, adult respiratory disease syndrome, chronic obstructive pulmonary disease (COPD), cryptogenic fibrosing alveolitis and bronchitis.