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1. WO2008029096 - P53 ACTIVATING BENZOYL UREA AND BENZOYL THIOUREA COMPOUNDS

Publication Number WO/2008/029096
Publication Date 13.03.2008
International Application No. PCT/GB2007/003302
International Filing Date 04.09.2007
Chapter 2 Demand Filed 04.07.2008
IPC
A61K 31/17 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
17having the group N-C(O)-N or N-C(S)-N, e.g. urea, thiourea, carmustine
CPC
A61P 21/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21Drugs for disorders of the muscular or neuromuscular system
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 3/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
A61P 31/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
18for HIV
Applicants
  • UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE [GB]/[GB] (AllExceptUS)
  • UNIVERSITY COURT OF THE UNIVERSITY OF ST. ANDREWS [GB]/[GB] (AllExceptUS)
  • LAIN, Sonia [GB]/[GB] (UsOnly)
  • LANE, David, Phillip [GB]/[GB] (UsOnly)
  • STARK, Michael, John, Raymond [GB]/[GB] (UsOnly)
  • MCCARTHY, Anna, Rose [GB]/[GB] (UsOnly)
  • HOLLICK, Jonathan, James [GB]/[GB] (UsOnly)
  • WESTWOOD, Nicholas, James [GB]/[GB] (UsOnly)
Inventors
  • LAIN, Sonia
  • LANE, David, Phillip
  • STARK, Michael, John, Raymond
  • MCCARTHY, Anna, Rose
  • HOLLICK, Jonathan, James
  • WESTWOOD, Nicholas, James
Agents
  • NAISMITH, Robert
Priority Data
0617278.704.09.2006GB
0625929.523.12.2006GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) P53 ACTIVATING BENZOYL UREA AND BENZOYL THIOUREA COMPOUNDS
(FR) COMPOSÉS D'ACTIVATION DE P53
Abstract
(EN) The present invention relates to compounds which acivate the p53 response, and find use in, for example, hyperproliferative diseases such as cancer treatment and potentially other diseases/conditions (involving sirtuin function).
(FR) La présente invention concerne des composés qui activent la réponse de P53, et s'emploient, par exemple, dans le traitement de maladies hyperprolifératives comme le cancer et, éventuellement, d'autres maladies ou états (impliquant la fonction de la sirtuine).
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