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1. (WO2008024725) AZA-BENZOFURANYL COMPOUNDS AND METHODS OF USE
Latest bibliographic data on file with the International Bureau   
Pub. No.: WO/2008/024725 International Application No.: PCT/US2007/076344
Publication Date: 28.02.2008 International Filing Date: 20.08.2007
IPC:
C07D 491/048 (2006.01) ,A61K 31/4355 (2006.01) ,A61K 31/5025 (2006.01) ,A61K 31/519 (2006.01) ,A61P 35/00 (2006.01) ,A61P 29/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
491
Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
044
with only one oxygen atom as ring hetero atom in the oxygen-containing ring
048
the oxygen-containing ring being five-membered
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
4355
the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
50
Pyridazines; Hydrogenated pyridazines
5025
ortho- or peri-condensed with heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
Applicants:
PRICE, Stephen [GB/GB]; GB (UsOnly)
WILLIAMS, Karen [GB/GB]; GB (UsOnly)
SAVY, Pascal Pierre [FR/GB]; GB (UsOnly)
DYKE, Hazel Joan [GB/GB]; GB (UsOnly)
MONTANA, John Gary [GB/GB]; GB (UsOnly)
STANLEY, Mark S. [US/US]; US (UsOnly)
BAO, Liang [CN/US]; US (UsOnly)
GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, California 94080-4990, US (AllExceptUS)
Inventors:
PRICE, Stephen; GB
WILLIAMS, Karen; GB
SAVY, Pascal Pierre; GB
DYKE, Hazel Joan; GB
MONTANA, John Gary; GB
STANLEY, Mark S.; US
BAO, Liang; US
Agent:
WANG, Min; Genentech, Inc. 1 DNA Way South San Francisco California 94080, US
Priority Data:
60/839,16121.08.2006US
60/871,59122.12.2006US
60/917,62311.05.2007US
60/944,74118.06.2007US
Title (EN) AZA-BENZOFURANYL COMPOUNDS AND METHODS OF USE
(FR) COMPOSÉS AZA-BENZOFURANYLE ET LEURS PROCÉDÉS D'UTILISATION
Abstract:
(EN) The invention relates to azabenzofuranyl compounds of Formula (I) with anti-cancer and/or anti-inflammatory activity and more specifically to azabenzofuranyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
(FR) L'invention concerne des composés aza-benzofuranyle de formule (I) présentant une activité anti-cancéreuse et/ou anti-inflammatoire, et en particulier des composés aza-benzofuranyle inhibant l'activité de la MEK-kinase. L'invention concerne des compositions et des procédés servant à inhiber une croissance cellulaire anormale ou à traiter un trouble hyperprolifératif, ou à traiter une maladie inflammatoire chez un mammifère. L'invention concerne également des procédés d'utilisation des composés de l'invention visant à diagnostiquer ou à traiter des cellules de mammifères in vitro, in situ, et in vivo pour des troubles pathologiques associés.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)