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1. WO2008024423 - 4-THIO SUBSTITUTED QUINOLINE AND NAPHTHYRIDINE COMPOUNDS

Publication Number WO/2008/024423
Publication Date 28.02.2008
International Application No. PCT/US2007/018607
International Filing Date 22.08.2007
IPC
A61K 31/47 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
CPC
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
C07D 215/36
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
36Sulfur atoms
C07D 401/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • XTL BIOPHARMACEUTICALS LTD. [US]/[US] (AllExceptUS)
  • YANG, Zhen [CN]/[US] (UsOnly)
  • FATHI, Reza [US]/[US] (UsOnly)
  • ZHU, Qiang [CN]/[US] (UsOnly)
  • CHO, Hyun, Joon [KR]/[US] (UsOnly)
  • LIU, Yixin [CA]/[US] (UsOnly)
  • SANDRASAGRA, Anthony [US]/[US] (UsOnly)
  • WOBBE, Richard, C. [US]/[US] (UsOnly)
Inventors
  • YANG, Zhen
  • FATHI, Reza
  • ZHU, Qiang
  • CHO, Hyun, Joon
  • LIU, Yixin
  • SANDRASAGRA, Anthony
  • WOBBE, Richard, C.
Agents
  • KENYON & KENYON LLP
Priority Data
60/839,92223.08.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) 4-THIO SUBSTITUTED QUINOLINE AND NAPHTHYRIDINE COMPOUNDS
(FR) COMPOSÉS À BASE DE QUINOLÉINE ET DE NAPHTYRIDINE À SUBSTITUTION THIO EN POSITION 4
Abstract
(EN)
The present invention relates to 4-thio substituted quinoline and naphthyridine derivatives and processes for their preparation. The invention also related to methods for treating infection of Hepatitis C virus by administering a 4-thio substituted quinoline or naphthyridine derivative.
(FR)
La présente invention concerne des derivés de quinoléine et de naphtyridine à substitution thio en position 4 et leurs procédés de préparation. L'invention concerne également des procédés de traitement d'infection du virus de l'hépatite C par l'administration de dérivé de quinoléine et de naphtyridine à substitution thio en position 4.
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