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1. WO2008023840 - PROGNOSTIC MARKERS AND THERAPEUTIC TARGETS FOR LUNG CANCER

Publication Number WO/2008/023840
Publication Date 28.02.2008
International Application No. PCT/JP2007/066825
International Filing Date 23.08.2007
IPC
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
C12Q 2600/158
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
158Expression markers
Applicants
  • ONCOTHERAPY SCIENCE, INC. [JP]/[JP] (AllExceptUS)
  • NAKAMURA, Yusuke [JP]/[JP] (UsOnly)
  • DAIGO, Yataro [JP]/[JP] (UsOnly)
  • NAKATSURU, Shuichi [JP]/[JP] (UsOnly)
Inventors
  • NAKAMURA, Yusuke
  • DAIGO, Yataro
  • NAKATSURU, Shuichi
Agents
  • SHIMIZU, Hatsushi
Priority Data
60/840,37625.08.2006US
60/894,80114.03.2007US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PROGNOSTIC MARKERS AND THERAPEUTIC TARGETS FOR LUNG CANCER
(FR) MARQUEURS PRONOSTIQUES ET CIBLES THÉRAPEUTIQUES S'APPLIQUANT AU CANCER DU POUMON
Abstract
(EN)
The present invention provides a diagnostic marker to detecting lung cancer. In particular, the present invention provides lung cancer marker genes i.e. KIF4A, MAPJD, NPTX, or FGFR1OP. The present invention further provides methods and kit for identifying compounds for treating lung cancer as well as methods for predicting a prognosis or diagnosis of lung cancer. In particular, the present invention provides methods and kits for identifying inhibitors of the interaction between KIF4A/ZNF549, KIF4A/ZNF553, MAPJD/MYC, or FGFR1OP/WRNIP1 which find utility in the treatment and prevention of lung. Alternatively, the present invention provides MAPJD associated with HAT complex as therapeutic target.
(FR)
La présente invention porte sur un marqueur diagnostique destiné à détecter le cancer du poumon, et notamment, sur des gènes de marqueurs du cancer du poumon, à savoir, KIF4A, MAPJD, NPTX ou FGFR1OP. La présente invention porte également sur des méthodes et des trousses d'identification de composés permettant de traiter le cancer du poumon, ainsi que sur des méthodes de prédiction d'un pronostic ou d'un diagnostic du cancer du poumon. La présente invention porte notamment sur des méthodes et sur des trousses d'identification d'inhibiteurs de l'interaction entre KIF4A/ZNF549, KIF4A/ZNF553, MAPJD/MYC ou FGFR1OP/WRNIP1 qui s'avèrent utiles dans le traitement et la prévention du cancer du poumon. Cette invention porte, en variante, sur MAPJD associé au complexe HAT comme cible thérapeutique.
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