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1. WO2008023268 - LEUKEMIA MOUSE MODEL CONDITIONALLY EXPRESSING A BCR-ABL ONCOGENE

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Publication Number WO/2008/023268
Publication Date 28.02.2008
International Application No. PCT/IB2007/003288
International Filing Date 23.08.2007
IPC
A01K 67/027 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67Rearing or breeding animals, not otherwise provided for; New breeds of animals
027New breeds of vertebrates
C07K 14/82 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
82Translation products from oncogenes
G01N 33/00 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
CPC
A01K 2207/15
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2207Modified animals
15Humanized animals
A01K 2217/00
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2217Genetically modified animals
A01K 2217/05
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2217Genetically modified animals
05Animals comprising random inserted nucleic acids (transgenic)
A01K 2217/20
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2217Genetically modified animals
20Animal model comprising regulated expression system
A01K 2227/105
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2227Animals characterised by species
10Mammal
105Murine
A01K 2267/0331
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2267Animals characterised by purpose
03Animal model, e.g. for test or diseases
0331Animal model for proliferative diseases
Applicants
  • UNIVERSIDAD DE SALAMANCA [ES]/[ES] (AllExceptUS)
  • CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS [ES]/[ES] (AllExceptUS)
  • SANCHEZ-GARCIA, Isidro [ES]/[ES] (UsOnly)
  • PEREZ-CARO, Maria [ES]/[ES] (UsOnly)
Inventors
  • SANCHEZ-GARCIA, Isidro
  • PEREZ-CARO, Maria
Agents
  • GOODFELLOW, Hugh, Robin
Priority Data
06017630.224.08.2006EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) LEUKEMIA MOUSE MODEL CONDITIONALLY EXPRESSING A BCR-ABL ONCOGENE
(FR) MODÈLE D'UN CANCER PROLONGÉ EXPRIMANT DE FAÇON CONDITIONNELLE UN ONCOGÈNE CHEZ LA SOURIS
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Abstract
(EN)
The invention relates, to cancer development; more specifically, leukaemia. In particular, the invention relates to transgenic non-human animals comprising in their genome a human oncogene which can be regulated exogenously by an effector substance. The invention further relates to transgenic non-human animals comprising in their genome the BCR-ABLp 190 gene. In addition the invention relates to the use of the transgenic non-human mammals of the invention for the discovery and development of compounds for the prevention and/or treatment of cancer.
(FR)
L'invention concerne le développement du cancer, de façon plus précise, de la leucémie. En particulier, l'invention concerne des animaux transgéniques comprenant, dans leur génome, un oncogène humain qui peut être régulé de façon exogène par une substance effectrice. L'invention concerne en outre des animaux transgéniques comprenant, dans leur génome, le gène BCR-ABLp 190. De plus, l'invention concerne l'utilisation des mammifères non humains transgéniques de l'invention pour la découverte et le développement de composés pour la prévention et/ou le traitement du cancer.
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