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1. WO2008022146 - POLYMER-SURFACTANT NANOPARTICLES FOR SUSTAINED RELEASE OF COMPOUNDS

Publication Number WO/2008/022146
Publication Date 21.02.2008
International Application No. PCT/US2007/075925
International Filing Date 14.08.2007
IPC
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
CPC
A61K 9/5161
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules ; having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
51Nanocapsules; Nanoparticles;
5107Excipients; Inactive ingredients
513Organic macromolecular compounds; Dendrimers
5161Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
A61P 17/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
06Antipsoriatics
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • WAYNE STATE UNIVERSITY [US]/[US] (AllExceptUS)
  • PANYAM, Jayanth [IN]/[US] (UsOnly)
  • PATIL, Mahesh, D. Chavan [IN]/[US] (UsOnly)
Inventors
  • PANYAM, Jayanth
  • PATIL, Mahesh, D. Chavan
Agents
  • POTTER, Jane, E.R.
Priority Data
60/837,80814.08.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) POLYMER-SURFACTANT NANOPARTICLES FOR SUSTAINED RELEASE OF COMPOUNDS
(FR) NANOPARTICULES DE POLYMÈRE-AGENT TENSIOACTIF POUR UNE LIBÉRATION SOUTENUE DE COMPOSÉS
Abstract
(EN)
A polymer-surfactant nanoparticle formulation, using the anionic surfactant aerosol OT (AOT) and polysaccharide polymer alginate, is used for sustained release of water-soluble drugs. The AOT-alginate nanoparticles are suitable for encapsulating doxorubicin, verapamil and clonidine, as well as therapeutic agents effective against dermal conditions such as psoriasis. The nanoparticles are also suitable for encapsulating photo-activated compounds such as methylene blue for use in photo-dynamic therapy of cancer and other diseases, and for treating tumor cells that exhibit resistance to at least one chemotherapeutic drug.
(FR)
L'invention concerne une formulation de nanoparticules de polymère-agent tensioactif comprenant de l'aérosol d'agent tensioactif anionique OT (AOT) et de l'alginate de polymère de polysaccharide. Ladite formulation est utilisée pour une libération continue de médicaments hydrosolubles. Les nanoparticules d'AOT-alginate sont adaptées pour encapsuler la doxorubicine, la vérapamil et la clonidine, de même que des agents thérapeutiques efficaces pour traiter des conditions de peau comme le psoriasis. Les nanoparticules sont également adaptées pour encapsuler des composés photo-activés, comme le bleu de méthylène, destinés à être utilisés dans une thérapie photodynamique du cancer et d'autres maladies, et pour traiter des cellules de tumeur qui présentent une résistance à au moins un médicament de chimiothérapie.
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Latest bibliographic data on file with the International Bureau