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1. WO2008020489 - REMEDY FOR INFLAMMATORY BOWEL DISEASE

Publication Number WO/2008/020489
Publication Date 21.02.2008
International Application No. PCT/JP2006/323673
International Filing Date 28.11.2006
IPC
A61K 45/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A61K 31/7088 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 1/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 29/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
C12Q 1/00 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
CPC
A61K 31/7088
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
A61K 38/4886
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
48acting on peptide bonds (3.4)
4886Metalloendopeptidases (3.4.24), e.g. collagenase
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applicants
  • 株式会社ステリック再生医科学研究所 STELIC INSTITUTE OF REGENERATIVE MEDICINE, STELIC INSTITUTE & CO. [JP]/[JP] (AllExceptUS)
  • 米山 博之 YONEYAMA, Hiroyuki [JP]/[JP] (UsOnly)
  • 若松 恭子 WAKAMATSU, Kyoko [JP]/[JP] (UsOnly)
Inventors
  • 米山 博之 YONEYAMA, Hiroyuki
  • 若松 恭子 WAKAMATSU, Kyoko
Agents
  • 清水 初志 SHIMIZU, Hatsushi
Priority Data
2006-22223817.08.2006JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) REMEDY FOR INFLAMMATORY BOWEL DISEASE
(FR) REMÈDE CONTRE LA MALADIE INFLAMMATOIRE INTESTINALE
(JA) 炎症性腸疾患改善剤
Abstract
(EN)
The inventor found for the first time that bowel inflammation can be efficiently inhibited by inhibiting the formation or accumulation of chondroitin sulfate proteoglycan. That is, by inhibiting the expression of versican which is one of the chondroitin sulfate proteoglycans using siRNA, inflammation in the large bowel could be inhibited. A compound such as a nucleic acid to be used for such an siRNA can be used as an agent effective in the inhibition of bowel inflammation. Further, this also indicates that the agent for inhibiting bowel inflammation can be found by screening a compound inhibiting the formation or accumulation of chondroitin sulfate proteoglycan.
(FR)
Selon l'inventeur de la présente invention, il s'avère pour la première fois que l'inflammation intestinale peut être efficacement enrayée par l'inhibition de la formation ou de l'accumulation de protéoglycane à sulfate de chondroïtine. Il serait ainsi possible d'enrayer l'inflammation du gros intestin en inhibant l'expression de versicane, qui est l'un des protéoglycanes à sulfate de chondroïtine, au moyen d'ARNsi. Un composé tel qu'un acide nucléique utilisé pour un tel ARNsi peut servir d'agent efficace pour l'inhibition de l'inflammation intestinale. Ceci indique également que l'agent permettant d'enrayer l'inflammation intestinale peut être trouvé par le criblage d'un composé inhibant la formation ou l'accumulation de protéoglycane à sulfate de chondroïtine.
(JA)
 本発明者は、コンドロイチン硫酸プロテオグリカンの生成もしくは蓄積を抑制することにより、腸炎症を効率的に抑制することが可能であることを初めて見出した。すなわち、コンドロイチン硫酸プロテオグリカンの1つであるバーシカンの発現をsiRNAにて抑制することで大腸における炎症を抑えることができた。このようなsiRNAに用いる核酸などの化合物は腸炎症抑制の有効な薬剤として利用できる。またこのことから、腸炎症抑制の薬剤はコンドロイチン硫酸プロテオグリカンの生成もしくは蓄積を抑制する化合物のスクリーニングにより見出されることも示された。
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