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1. (WO2008016288) BENZIMIDAZO[1,2-C][1,2,3]THIADIAZOL-7-SULFONAMIDES AS INHIBITORS OF CARBONIC ANHYDRASE AND THE INTERMEDIATES FOR PRODUCTION THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2008/016288 International Application No.: PCT/LT2007/000005
Publication Date: 07.02.2008 International Filing Date: 01.08.2007
IPC:
C07D 513/04 (2006.01) ,A61K 31/4188 (2006.01) ,A61P 27/06 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
513
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/, C07D477/232
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164
1,3-Diazoles
4188
condensed with heterocyclic ring systems, e.g. biotin, sorbinil
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27
Drugs for disorders of the senses
02
Ophthalmic agents
06
Antiglaucoma agents or miotics
Applicants:
BIOTECHNOLOGIJOS INSTITUTAS [LT/LT]; V. Graiciuno g. 8 LT-02241 Vilnius, LT (AllExceptUS)
MATULIS, Daumantas [LT/LT]; LT (UsOnly)
DUDUTIENE, Virginija [LT/LT]; LT (UsOnly)
MATULIENE, Jurgita [LT/LT]; LT (UsOnly)
MISTINAITE, Lina [LT/LT]; LT (UsOnly)
Inventors:
MATULIS, Daumantas; LT
DUDUTIENE, Virginija; LT
MATULIENE, Jurgita; LT
MISTINAITE, Lina; LT
Agent:
GERASIMOVIC, Liudmila; Vingriu g. 13-42 LT-01141 Vilnius, LT
Priority Data:
2006 06602.08.2006LT
Title (EN) BENZIMIDAZO[1,2-C][1,2,3]THIADIAZOL-7-SULFONAMIDES AS INHIBITORS OF CARBONIC ANHYDRASE AND THE INTERMEDIATES FOR PRODUCTION THEREOF
(FR) BENZIMIDAZO[1,2-C][1,2,3]THIADIAZOL-7-SULFAMIDES EN TANT QU'INHIBITEURS D'UNE ANHYDRASE CARBONIQUE ET LEURS INTERMÉDIAIRES DE PRODUCTION
Abstract:
(EN) The invention is related to novel compounds - benzimidazo[1,2-c][1,2,3]thiadiazole sulfonamides, corresponding to the general formula (I). The compounds can be used in biomedicine as active ingredients in pharmaceutical formulations, because they inhibit enzymes which participate in disease progression such as glaucome. The compounds of formula (I) inhibits enzymes such as carbonic anhydrases and metallo proteinases. This invention is also related to new intermediate compounds which are used for the synthesis of sulfonamides of formula (I).
(FR) La présente invention concerne des composés innovants de benzimidazo[1,2-c][1,2,3]thiadiazole sulfamides, correspondant à la formule générale (I). (I) Les composés peuvent être utilisés en bio-médecine en tant que matière active dans des formulations pharmaceutiques parce qu'ils inhibent des enzymes qui participent à la progression d'une maladie telle que le glaucome. Les composés de formule (I) inhibent des enzymes telles que les anhydrases carboniques et les métallo-protéinases. L'invention concerne également des nouveaux composés intermédiaires qui sont utilisés pour la synthèse des sulfamides de formule (I).
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2054420EP2054420