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1. (WO2008008432) SUBSTITUTED CHIRAL FUSED( 1,2) IMIDAZO (4,5-C) RING COMPOUNDS AND METHODS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2008/008432 International Application No.: PCT/US2007/015894
Publication Date: 17.01.2008 International Filing Date: 12.07.2007
IPC:
C07D 498/14 (2006.01) ,A61K 31/5365 (2006.01) ,A61P 31/12 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
498
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
12
in which the condensed system contains three hetero rings
14
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
535
having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
5365
ortho- or peri-condensed with heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
COLEY PHARMACEUTICAL GROUP, INC. [US/US]; 235 East 42nd Street New York, NY 10017-5755, US (AllExceptUS)
GRIESGRABER, George, W. [US/US]; US (UsOnly)
JOHANNESSEN SLANIA, Sarah [US/US]; US (UsOnly)
Inventors:
GRIESGRABER, George, W.; US
JOHANNESSEN SLANIA, Sarah; US
Agent:
GATES, Edward, R.; Wolf, Greenfield & Sacks, P.C. 600 Atlantic Avenue Boston, MA 02210, US
Priority Data:
60/807,15512.07.2006US
Title (EN) SUBSTITUTED CHIRAL FUSED( 1,2) IMIDAZO (4,5-C) RING COMPOUNDS AND METHODS
(FR) COMPOSÉS À CYCLE [1,2] IMIDAZO [4,5-C] FUSIONNÉ CHIRAL SUBSTITUÉ ET PROCÉDÉS CORRESPONDANTS
Abstract:
(EN) Substituted fused [l,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5- c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinoIines, imidazo[4,5-c]naphthyridines, 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines, and imidazo[4,5-c]pyridines ) with a -CHC-R2)- group in the fused ring at the 2-position of the imidazo ring and a.-CH(-Ri)- group in the fused ring at the 1 -position of the imidazo ring, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
(FR) L'invention concerne des composés à cycle [l,2]imidazo[4,5-c] fusionné substitué (par exemple des imidazo[4,5- c]quinolines, 6,7,8,9-tétrahydroimidazo[4,5-c]quinoléines, imidazo[4,5-c]naphtyridines, 6,7,8,9-tétrahydroimidazo[4,5-c]naphtyridines, et imidazo[4,5-c]pyridines) avec un groupe -CHC-R2- dans le noyau fusionné en position 2 du noyau imidazo et un groupe -CH(-Ri)- dans le noyau fusionné en position 1 du noyau imidazo, des compositions pharmaceutiques contenant les composés, des intermédiaires, des procédés de fabrication des composés et des procédés d'utilisation de ces composés comme immunomodulateurs, pour induire la biosynthèse des cytokines dans des animaux et dans le traitement de maladies comprenant les maladies virales et néoplasiques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)