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1. WO2007150025 - PURINONE DERIVATIVES AS HM74A AGONISTS

Publication Number WO/2007/150025
Publication Date 27.12.2007
International Application No. PCT/US2007/071891
International Filing Date 22.06.2007
IPC
C07D 487/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
12in which the condensed system contains three hetero rings
14Ortho-condensed systems
CPC
A61P 3/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
A61P 3/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
06Antihyperlipidemics
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
A61P 5/50
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
5Drugs for disorders of the endocrine system
48of the pancreatic hormones
50for increasing or potentiating the activity of insulin
A61P 9/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applicants
  • INCYTE CORPORATION [US]/[US] (AllExceptUS)
  • ZHENG, Changsheng [US]/[US] (UsOnly)
  • XUE, Chu-Biao [US]/[US] (UsOnly)
  • CAO, Ganfeng [CN]/[US] (UsOnly)
  • XIA, Michael [US]/[US] (UsOnly)
  • WANG, Anlai [CN]/[US] (UsOnly)
  • YE, Hai, Fen [CN]/[US] (UsOnly)
  • METCALF, Brian [US]/[US] (UsOnly)
Inventors
  • ZHENG, Changsheng
  • XUE, Chu-Biao
  • CAO, Ganfeng
  • XIA, Michael
  • WANG, Anlai
  • YE, Hai, Fen
  • METCALF, Brian
Agents
  • SHAO, Feng
Priority Data
60/815,95523.06.2006US
60/922,81811.04.2007US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PURINONE DERIVATIVES AS HM74A AGONISTS
(FR) DÉRIVÉS DE PURINONE EN TANT QU'AGONISTES DU HM74A
Abstract
(EN)
The present invention relates to purinone derivatives which are agonists of the HM74a receptor. Further provided are compositions and methods of using the compounds herein, and their pharmaceutically acceptable salts for the treatment of disease.
(FR)
La présente invention concerne des dérivés de purinone qui sont agonistes du récepteur HM74a. La présente invention concerne en outre des compositions et des procédés d'utilisation des composés selon l'invention, et leurs sels pharmaceutiquement acceptables pour le traitement de maladies.
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