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1. WO2007149938 - METHODS FOR PROMOTING HAIR GROWTH

Publication Number WO/2007/149938
Publication Date 27.12.2007
International Application No. PCT/US2007/071695
International Filing Date 20.06.2007
IPC
A61K 38/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
12Cyclic peptides
CPC
A61K 38/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
A61P 17/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
14for baldness or alopecia
Applicants
  • THE SALK INSTITUTE BIOLOGICAL STUDIES [US]/[US] (AllExceptUS)
  • THE REGENTS OF UNIVERSITY OF CALIFORNIA [US]/[US] (AllExceptUS)
  • MILLION, Mulugeta [US]/[US] (UsOnly)
  • WANG, Lixin [CN]/[US] (UsOnly)
  • TACHE, Yvette [US]/[US] (UsOnly)
  • RIVIER, Jean [CH]/[US] (UsOnly)
Inventors
  • MILLION, Mulugeta
  • WANG, Lixin
  • TACHE, Yvette
  • RIVIER, Jean
Agents
  • RYBAK, Sheree, Lynn
Priority Data
60/805,38921.06.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR PROMOTING HAIR GROWTH
(FR) PROCÉDÉ FAVORISANT LA POUSSE DES CHEVEUX
Abstract
(EN)
This disclosure reveals that cyclic corticotrophin releasing factor (CRF) antagonist peptides (such as astressin B, its functional fragments, and their derivatives) induce hair growth and prevent hair loss in vivo. This important discovery enables, for instance, methods of promoting hair growth, and methods of treating hair loss (such as the hair loss that occurs normally in some individuals or that is the result of a health disorder or therapeutic treatment). Exemplary cyclic CRF antagonist peptides useful in the disclosed methods are provided throughout the disclosure.
(FR)
Selon la présente invention, les peptides antagonistes du facteur de libération cyclique de corticotrophine (CRF), notamment l'astressine B, ses fragments fonctionnels et ses dérivés, induisent in vivo la pousse des cheveux et évitent leur chute. Cette découverte importante donne lieu par exemple, à des procédés permettant de favoriser la pousse des cheveux et à des procédés permettant de lutter contre la chute des cheveux (par exemple chute naturelle ou résultant d'un trouble de la santé ou d'un traitement thérapeutique). La description donne des exemples de peptides antagonistes du CRF utiles dans le cadre des procédés de l'invention.
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