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1. WO2007149902 - ANTI-INFLAMMATORY DISSOLVABLE FILM

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[ EN ]

What is claimed:
1. A slowly dissolvable film comprising:
herbal bioactive agent(s); and
polymer(s), dissolvable in the aggregate,
wherein the film becomes adhesive as it is placed against a mucosal surface and begins to absorb moisture therefrom.

2. The film of claim 1, wherein the film polymer(s) and other film components are selected to provide a mucosal residence time of 5 minutes or more

3. The film of claim 1 , comprising tear lines to aid a user to tear our a piece that is shaped or sized more appropriately for an intended administration site.

4. The film of claim 1, wherein component(s) of Sambucus nigra comprises 51 to 100% by weight of plant extract solids or herbal bioactive agent(s) in the film.

5. The film of claim 4, wherein components of a second plant comprises from 1 to 50% by weight of plant extract solids or herbal bioactive agent(s) in the film.

6. The film of claim 5, wherein components of a third plant comprises from 0.5 to 5% by weight of plant extract solids or herbal bioactive agent(s) in the film.

7. The film of claim 1, wherein the film has two layers, one with polymers selected to be adhesive, and one with polymers selected to be, on the whole, relatively less dissolvable than those of the adhesive layer, wherein said layers are, in the aggregate, dissolvable.

8. The film of claim 7, wherein the herbal extract(s) are substantially in the adhesive layer.

9. The film of claim 1, further comprising one or more anti -inflammatory agents.

10. A film application kit comprising: a cosmetic or bioactive agent and a film comprising polymer(s), dissolvable in the aggregate, wherein the film becomes adhesive as it is placed against a mucosal surface and begins to absorb moisture therefrom; and
an applicator to which the film is releasable attached such that the film can be placed with the applicator against a mucosal surface to provide sufficient adhesion such that the applicator can be pulled, torn or peeled from the film substantially without displacing the film.

11. The film application kit of claim 10, wherein the applicator comprises a handle.

12. The film application kit of claim 11 , wherein the handle comprises a ring shape with a ring opening sized to accept at least the tip of a finger.

13. The film application kit of claim 11, wherein the applicator comprises a swivel member allowing the film to rotate with respect to the handle.

14. A method of treating an indication of mucosal or adjacent tissue comprising periodically applying to mucosa at or adjacent to disease affected tissue a film comprising
herbal bioactive agent(s); and
polymers, dissolvable in the aggregate, wherein the film becomes adhesive as it is placed against a mucosal surface and begins to absorb moisture therefrom.

15. The method of claim 14, wherein the indication is of the oral cavity.

16. The method of claim 15, wherein the indication is aphthous ulceration.

17. The method of claim 15, wherein the indication is a mucosal lesion secondary to chemotherapy or radiation treatment.

18. A method of applying a film to a mucosal surface comprising:
providing: a cosmetic or bioactive agent and a film comprising polymer(s),
dissolvable in the aggregate, wherein the film becomes adhesive as it is placed against a mucosal surface and begins to absorb moisture
therefrom; and
an applicator to which the film is releasable attached such that the film
can be placed with the applicator against a mucosal surface to provide sufficient adhesion such that the applicator can be pulled, torn or
peeled from the film substantially without displacing the film from the mucosa; and
manipulating the applicator to position the film on the mucosal surface.

19. The method of claim 18, wherein the applicator is manipulated with handle comprised in the applicator.

20. The method of claim 19, wherein the handle is manipulated by inserting at least a portion of a finger into a ring opening comprised in the handle.

21. The method of claim 19, wherein during the manipulating the handle is rotated with respect to the film.