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1. WO2007149873 - KV1.5 POTASSIUM CHANNEL INHIBITORS

Publication Number WO/2007/149873
Publication Date 27.12.2007
International Application No. PCT/US2007/071586
International Filing Date 19.06.2007
IPC
C07D 471/10 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
10Spiro-condensed systems
A61K 31/505 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
A61P 9/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
06Antiarrhythmics
CPC
A61P 25/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
04Centrally acting analgesics, e.g. opioids
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
A61P 9/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
A61P 9/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
06Antiarrhythmics
C07D 471/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
10Spiro-condensed systems
Applicants
  • WYETH [US]/[US] (AllExceptUS)
  • JANUSZ, John, Michael [US]/[US] (UsOnly)
  • WU, Shengde [US]/[US] (UsOnly)
  • FAIRWEATHER, Neil, T. [US]/[US] (UsOnly)
  • LEE, Wenlin (UsOnly)
  • BLASS, Benjamin, E. [US]/[US] (UsOnly)
  • FLUXE, Andrew, J. [US]/[US] (UsOnly)
  • HODSON, Stephen, J. [US]/[US] (UsOnly)
  • RIDGEWAY, James, M, II [US]/[US] (UsOnly)
Inventors
  • JANUSZ, John, Michael
  • WU, Shengde
  • FAIRWEATHER, Neil, T.
  • LEE, Wenlin
  • BLASS, Benjamin, E.
  • FLUXE, Andrew, J.
  • HODSON, Stephen, J.
  • RIDGEWAY, James, M, II
Agents
  • BARNHARD, Elizabeth, M.
Priority Data
60/815,06620.06.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) KV1.5 POTASSIUM CHANNEL INHIBITORS
(FR) INHIBITEURS DU CANAL POTASSIQUE KV1.5
Abstract
(EN)
The present invention relates to 4-oxo-1,3,8-triaza-spiro[4.5]decanes which are useful as Kv1.5 potassium channel inhibitors providing atrial-selective antiarrhythmic activity. The present invention further relates to compositions and methods for treating atrial-selective antiarrhythmia.
(FR)
la présente invention concerne des 4-oxo-1,3,8-triaza-spiro[4.5]décanes convenant comme inhibiteurs du canal potassique Kv1.5 du fait qu'ils exercent une activité anti-arythmique à sélectivité auriculaire. De plus, cette invention concerne des compositions et une méthode de traitement anti-arythmie à sélectivité auriculaire.
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