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1. WO2007149343 - PROTEASES FOR TREATMENT OF VENOMOUS BITES

Publication Number WO/2007/149343
Publication Date 27.12.2007
International Application No. PCT/US2007/014112
International Filing Date 15.06.2007
IPC
A01N 37/00 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
37Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
A01N 63/00 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
63Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
A61K 38/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
48acting on peptide bonds (3.4)
C12N 9/72 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
48acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
72Urokinase
CPC
A61K 38/4813
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
48acting on peptide bonds (3.4)
4813Exopeptidases (3.4.11. to 3.4.19)
A61K 38/482
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
48acting on peptide bonds (3.4)
482Serine endopeptidases (3.4.21)
A61K 38/4826
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
48acting on peptide bonds (3.4)
482Serine endopeptidases (3.4.21)
4826Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
A61K 38/4873
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
48acting on peptide bonds (3.4)
4873Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
Applicants
  • THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY [US]/[US] (AllExceptUS)
  • METZ, Martin [DE]/[US] (UsOnly)
  • GALLI, Stephen, J. [US]/[US] (UsOnly)
Inventors
  • METZ, Martin
  • GALLI, Stephen, J.
Agents
  • ASTON, David, J.
Priority Data
60/814,43216.06.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PROTEASES FOR TREATMENT OF VENOMOUS BITES
(FR) PROTÉASES DESTINÉES AU TRAITEMENT DE MORSURES VENIMEUSES
Abstract
(EN)
The present disclosure is directed to methods and materials, including kits, for use in treating snakebites, bee stings, spider bites, and other envenomation or exposure to toxins not derived from animals. The methods and materials encompass proteases, which have been found to increase survival and reduce toxic effects, such as temperature loss, and, in experimental animals, death. The proteases have been found to be part of a protective mechanism associated with mast cell degranulation. Preferred proteases include certain proteases found in mast cells, such as chymases (chymotrypsin-like substrate specificity), carboxypeptidase A and tryptases (trypsin-like substrate specificity). Other proteases, such as carboxypeptidase B, chymotrypsin or papain may also be employed. Further provided are kits and dosage forms for convenient and rapid delivery of treatment in case of envenomation. Such dosage forms are based on internal, rather than topical delivery.
(FR)
La présente invention concerne des procédés et des matériaux, y compris des trousses, destinés à être utilisés pour le traitement de morsures de serpent, de piqûres d'abeilles, de morsures d'araignées, et d'autres envenimations ou expositions à des toxines qui ne sont pas dérivées d'animaux. Les procédés et matériaux englobent des protéases, dont il a été constaté qu'elles augmentaient le taux de survie et réduisaient les effets toxiques, tels qu'une déperdition de température, et, dans le cas d'animaux de laboratoire, la mort. Il a été trouvé que les protéases faisaient partie d'un mécanisme de protection associé à une dégranulation mastocytaire. Les protéases préférées incluent certaines protéases trouvées dans les mastocytes, telles que des chymases (spécificité d'un substrat de type chymotrypsine), des carboxypeptidases A et des tryptases (spécificité d'un substrat de type trypsine). D'autres protéases, telles que les carboxypeptidases B, les chymotrypsines ou les papaïnes peuvent également être utilisées. L'invention concerne en outre des trousses et des formes posologiques permettant une administration aisée et rapide d'un traitement dans le cas d'une envenimation. De telles formes posologiques sont basées sur une administration interne plutôt que topique.
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