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1. WO2007149130 - COMPOSITION AND METHOD FOR VASCULAR EMBOLIZATION

Publication Number WO/2007/149130
Publication Date 27.12.2007
International Application No. PCT/US2007/001606
International Filing Date 22.01.2007
Chapter 2 Demand Filed 10.04.2008
IPC
A61F 2/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
CPC
A61L 24/043
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
24Surgical adhesives or cements; Adhesives for colostomy devices
04containing macromolecular materials
043Mixtures of macromolecular materials
A61L 24/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
24Surgical adhesives or cements; Adhesives for colostomy devices
04containing macromolecular materials
08Polysaccharides
A61L 2430/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2430Materials or treatment for tissue regeneration
36for embolization or occlusion, e.g. vaso-occlusive compositions or devices
Applicants
  • ENDOMEDIX, INC. [US]/[US] (AllExceptUS)
  • ABRAHAMS, John, M. [US]/[US] (UsOnly)
  • CHEN, Weiliam [US]/[US] (UsOnly)
Inventors
  • ABRAHAMS, John, M.
  • CHEN, Weiliam
Agents
  • STEFFEY, Charles, E.
Priority Data
11/425,28020.06.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITION AND METHOD FOR VASCULAR EMBOLIZATION
(FR) COMPOSITION ET PROCÉDÉ DESTINÉS À UNE EMBOLISATION VASCULAIRE
Abstract
(EN)
A therapeutic composition and a therapeutic method are provided for occlusion of a vascular site. The vascular site may be within a blood vessel or a lymph duct, and may include an aneurysm or an arteriovenous malformation, or may be in a normal section of the vessel or duct. A composition comprises an alkylated chitosan, and a polybasic carboxylic acid or an oxidized polysaccharide, or both, in an aqueous medium. Another composition comprises a gelatin and a polybasic carboxylic acid or an oxidized polysaccharide, or both, in an aqueous medium The composition is in the form of a substantially liquid sol immediately upon mixing, and gels or solidifies in situ in the vascular site, typically in a matter of minutes. The composition may further include a radiopaque agent or a bioactive agent, which may be contained in nanospheres or microspheres within the hydrogel.
(FR)
La présente invention concerne une composition thérapeutique et un procédé thérapeutique permettant de réaliser l'occlusion d'un site vasculaire. Le site vasculaire peut être situé dans un vaisseau sanguin ou un conduit lymphatique, et il peut comporter un anévrisme ou une malformation artério-veineuse, ou il peut également être situé dans une section normale du vaisseau ou du conduit. Une composition contient un chitosan alkylé et un acide carboxylique polybasique ou un polysaccharide oxydé, ou l'un et l'autre, dans un milieu aqueux. Une autre composition contient une gélatine et un acide carboxylique polybasique ou un polysaccharide oxydé, ou l'un et l'autre, dans un milieu aqueux. La composition se trouve sous la forme d'un sol sensiblement liquide lors du mélange, et se transforme en gel ou se solidifie in situ dans le site vasculaire, généralement en quelques minutes. La composition peut en outre contenir un agent radio-opaque ou un agent bioactif, qui peut être contenu dans des nanosphères ou des microsphères de l'hydrogel.
Also published as
Latest bibliographic data on file with the International Bureau