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1. WO2007149012 - LIVE TULAREMIC VACCINE NIK-SP.F. TULARENSIS

Publication Number WO/2007/149012
Publication Date 27.12.2007
International Application No. PCT/RU2007/000330
International Filing Date 15.06.2007
IPC
A61K 39/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
A61K 35/74 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
C12N 1/00 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
A61P 31/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
CPC
A61K 35/74
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
A61K 39/0208
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
0208Specific bacteria not otherwise provided for
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
C12N 1/36
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof
36Adaptation or attenuation of cells
C12R 1/01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
RPROCESSES USING MICROORGANISMS
1Processes using microorganisms
01using bacteria or actinomycetales
Applicants
  • ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ «БИОТЭК» OBSCHESTVO S OGRANICHENNOY OTVETSTVENNOSTYU 'BIOTEC' [RU]/[RU] (AllExceptUS)
  • КИСЛИЧКИН Николай Николаевич KISLICHKIN, Nikolay Nikolaevich [RU]/[RU] (UsOnly)
  • КИСЛИЧКИНА Ольга Ивановна KISLICHKINA, Olga Ivanovna [RU]/[RU] (UsOnly)
Inventors
  • КИСЛИЧКИН Николай Николаевич KISLICHKIN, Nikolay Nikolaevich
  • КИСЛИЧКИНА Ольга Ивановна KISLICHKINA, Olga Ivanovna
Common Representative
  • ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ «БИОТЭК» OBSCHESTVO S OGRANICHENNOY OTVETSTVENNOSTYU 'BIOTEC'
Priority Data
200612112016.06.2006RU
Publication Language Russian (RU)
Filing Language Russian (RU)
Designated States
Title
(EN) LIVE TULAREMIC VACCINE NIK-SP.F. TULARENSIS
(FR) VACCIN TULARÉMIQUE VIVANT DE NIK-SP.F. TULARENSIS
(RU) ЖИВАЯ ТУЛЯРЕМИЙНАЯ ВАКЦИНА NIK-SP.F. TULARENSIS
Abstract
(EN)
The invention relates medicine and veterinary science. The inventive live tularemic vaccine comprises Francisella tularensis NIK-sp strain which is deposited in the All-Rassian collection of industrial microorganisms FGUP GosNIIGenetica under index VKPM B-9311 and obtained by selecting according to a microbiological method from a pure line of R-form bacteria of a 15 NIIEG Francisella tularensis strain which is S-shaped with a maximum immunising dose for laboratory animals at a subcutaneous administration ranging from 1x104to 1x108 of microbial cells and is capable to protect them against infection with Francisella tularensis subsp. tularensis 503.
(FR)
L'invention appartient au domaine de la santé publique et de la médecine vétérinaire. Elle concerne plus particulièrement un vaccin vivant contre la tularémie qui comprend la souche Francisella tularensis NIK-sp déposée auprès de la Collection nationale russe des micro-organismes industriels GUP GosNIIGenetica sous la référence VKPM B-9311, qui a été obtenue au moyen de la sélection microbiologique à partir de la lignée pure des bactérie de la forme R de la souche 15 NIIEG Francisella tularensis de la bactérie de forme R, qui se présente comme une forme S avec une dose d'immunisation maximale pour les animaux de laboratoire lors de l'injection sous-cutanée de 1x104 à 1x108de cellules microbiennes, et un procédé de leur protection contre l'infection par Francisella tularensis subsp. tularensis 503.
(RU)
Изобретение относится к медицине и ветеринарии. Живая туляремийная вакцина включает штамм Francisella tularensis NIK-sp, депонированный во Всероссийской коллекции промышленных микроорганизмов ФГУП ГосНИИГенетика за индексом VKPM B-9-311, полученный путем селекции микробиологическим способом из чистой линии бактерий R- формы штамма 15 НИИЭГ Francisella tularensis, представляющий собой S-форму с максимальной иммунизирующей дозой для лабораторных животных при подкожном введении от 1x104 до 1x108 микробных клеток, и егтособеный защищать их от инфицирования Francisella tularensis subsp. tularensis 503.
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