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1. WO2007148804 - COMPOSITION CAPABLE OF PROMOTING THE PRODUCTION OF HYALURONIC ACID

Publication Number WO/2007/148804
Publication Date 27.12.2007
International Application No. PCT/JP2007/062636
International Filing Date 22.06.2007
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 8/34 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
33containing oxygen
34Alcohols
A61K 8/64 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
64Proteins; Peptides; Derivatives or degradation products thereof
A61K 31/07 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
07Retinol compounds, e.g. vitamin A
A61P 17/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
16Emollients or protectives, e.g. against radiation
A61P 19/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
CPC
A61K 2800/70
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2800Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
70Biological properties of the composition as a whole
A61K 38/07
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
07Tetrapeptides
A61K 8/64
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
64Proteins; Peptides; Derivatives or degradation products thereof
A61K 8/671
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
67Vitamins
671Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
A61P 17/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
16Emollients or protectives, e.g. against radiation
A61P 19/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
Applicants
  • ロート製薬株式会社 ROHTO PHARMACEUTICAL CO., LTD. [JP]/[JP] (AllExceptUS)
  • 瀧口 久美子 TAKIGUCHI, Kumiko [JP]/[JP] (UsOnly)
  • 本間 陽一 HONMA, Yoichi [JP]/[JP] (UsOnly)
  • 菊地 数晃 KIKUCHI, Kazuaki [JP]/[JP] (UsOnly)
  • 常次 修一 TSUNETSUGU, Shuichi [JP]/[JP] (UsOnly)
  • 稲岡 賢 INAOKA, Satoshi [JP]/[JP] (UsOnly)
Inventors
  • 瀧口 久美子 TAKIGUCHI, Kumiko
  • 本間 陽一 HONMA, Yoichi
  • 菊地 数晃 KIKUCHI, Kazuaki
  • 常次 修一 TSUNETSUGU, Shuichi
  • 稲岡 賢 INAOKA, Satoshi
Agents
  • 佐伯 憲生 SAEKI, Norio
Priority Data
2006-17462523.06.2006JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) COMPOSITION CAPABLE OF PROMOTING THE PRODUCTION OF HYALURONIC ACID
(FR) COMPOSITION CAPABLE DE FAVORISER LA PRODUCTION D'ACIDE HYALURONIQUE
(JA) ヒアルロン酸産生促進能を有する組成物
Abstract
(EN)
Disclosed is a novel composition capable of remarkably promoting the production of hyaluronic acid. The composition comprises (A) at least one member selected from the group consisting of retinol and a derivative thereof and (B) at least one member selected from the group consisting of a peptide represented by Leu-Glu-His-Ala (Formula I), a derivative thereof and a salt of the peptide or the derivative. Alternatively, the composition comprises (A) at least one member selected from the group consisting of retinol and a derivative thereof and (B) at least one member selected from the group consisting of a peptide having the conservative substitution, deletion and/or addition of at least one amino acid residue in the amino acid sequence: Leu-Glu-His-Ala (Formula I) and capable of promoting the production of hyaluronic acid in a cell, a derivative thereof and a salt of the peptide or the derivative.
(FR)
L'invention concerne une nouvelle composition capable de favoriser remarquablement la production d'acide hyaluronique. La composition contient: (A) au moins un élément sélectionné dans le groupe constitué par le rétinol et par un dérivé de celui-ci, et (B) au moins un élément sélectionné dans le groupe constitué par un peptide représenté par Leu-Glu-His-Ala (formule I), un dérivé de celui-ci et un sel du peptide ou du dérivé. Dans une variante, la composition contient: (A) au moins un élément sélectionné dans le groupe constitué par le rétinol et par un dérivé de celui-ci, et (B) au moins un élément sélectionné dans le groupe constitué par un peptide présentant une substitution conservatrice, une suppression et/ou une addition d'au moins un résidu d'acide aminé dans la séquence d'acide aminé: Leu-Glu-His-Ala (formule I), et est capable de favoriser la production d'acide hyaluronique dans une cellule, un dérivé de celui-ci et un sel du peptide ou du dérivé.
(JA)
 本発明は、顕著なヒアルロン酸産生促進能を有する新規組成物を提供することを目的とし、(A)レチノール及びその誘導体からなる群より選択される少なくとも一種と、(B)Leu-Glu-His-Ala(式I)で表されるペプチド、その誘導体及びそれらの塩からなる群より選択される少なくとも一種とを含有する組成物を提供する。本発明はさらに、(A)レチノール及びその誘導体からなる群より選択される少なくとも一種と、(B)Leu-Glu-His-Ala(式I)のアミノ酸配列において1個以上のアミノ酸の保存的置換、欠失および/または付加を有し且つ細胞におけるヒアルロン酸産生促進能を有するペプチド、その誘導体及びそれらの塩からなる群より選択される少なくとも一種とを含有する組成物を提供する。
Also published as
Latest bibliographic data on file with the International Bureau