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1. WO2007148798 - REDUCED COENZYME Q10-CONTAINING COMPOSITION AND METHOD FOR PRODUCING THE SAME

Publication Number WO/2007/148798
Publication Date 27.12.2007
International Application No. PCT/JP2007/062627
International Filing Date 22.06.2007
IPC
A61K 31/09 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
075Ethers or acetals
085having an ether linkage to aromatic ring nuclear carbon
09having two or more such linkages
A61K 9/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
A61K 47/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen
10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols ; Poloxamers; PEG/POE alkyl ethers
A61K 47/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen
14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
A61K 47/24 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
24containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
A61K 47/26 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
CPC
A61K 31/122
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
12Ketones
122having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
A61K 9/0056
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0053Mouth and digestive tract, i.e. intraoral and peroral administration
0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
A61K 9/107
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
107Emulsions ; ; Emulsion preconcentrates; Micelles
A61K 9/1652
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1605Excipients; Inactive ingredients
1629Organic macromolecular compounds
1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
A61K 9/1664
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1605Excipients; Inactive ingredients
1664Compounds of unknown constitution, e.g. material from plants or animals
A61K 9/2018
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2004Excipients; Inactive ingredients
2013Organic compounds, e.g. phospholipids, fats
2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
Applicants
  • 株式会社カネカ KANEKA CORPORATION [JP]/[JP] (AllExceptUS)
  • 植田 貴志 UEDA, Takashi [JP]/[JP] (UsOnly)
  • 赤尾 信介 AKAO, Shinsuke [JP]/[JP] (UsOnly)
  • 北村 志郎 KITAMURA, Shiro [JP]/[JP] (UsOnly)
  • 岸田 秀之 KISHIDA, Hideyuki [JP]/[JP] (UsOnly)
  • 植田 尚宏 UEDA, Takahiro [JP]/[JP] (UsOnly)
Inventors
  • 植田 貴志 UEDA, Takashi
  • 赤尾 信介 AKAO, Shinsuke
  • 北村 志郎 KITAMURA, Shiro
  • 岸田 秀之 KISHIDA, Hideyuki
  • 植田 尚宏 UEDA, Takahiro
Agents
  • 高島 一 TAKASHIMA, Hajime
Priority Data
2006-17208622.06.2006JP
2007-11487724.04.2007JP
60/829,24012.10.2006US
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) REDUCED COENZYME Q10-CONTAINING COMPOSITION AND METHOD FOR PRODUCING THE SAME
(FR) COMPOSITION CONTENANT DE LA COENZYME Q10 RÉDUITE ET PROCÉDÉ DE PRODUCTION DE CELLE-CI
(JA) 還元型補酵素Q10含有組成物およびその製造方法
Abstract
(EN)
It is intended to provide a granular composition containing reduced coenzyme Q10, which has high oxidative stability and high biological absorption and in which an oily component containing reduced coenzyme Q10 forms domains and is polydispersed in a matrix containing a water-soluble excipient, a method for producing the same, and a method for stabilizing the same. Further, it is intended to provide a food, a food with nutrient function claims, a food for specified health use, a nutritious supplement, a nutrient, an animal drug, a drink, a feed, a pet food, a cosmetic, a drug, a therapeutic agent, a preventive agent and the like.
(FR)
La présente invention concerne une composition granulaire contenant de la coenzyme Q10 réduite, caractérisée par une excellente stabilité oxydative et une absorption biologique élevée et dans laquelle un composant huileux contenant la coenzyme Q10 réduite forme des domaines et est polydispersé dans une matrice contenant un excipient hydrosoluble, un procédé de production de ladite composition et un procédé de stabilisation de ladite composition. L'invention concerne en outre un aliment, un aliment revendiquant une fonction nutritive, un aliment ayant un intérêt spécifique en termes de santé, un complément alimentaire, un nutriment, un médicament à usage animal, une boisson, un aliment à usage animal, un aliment destiné aux animaux de compagnie, un produit cosmétique, un médicament, un agent thérapeutique, un agent préventif et équivalent.
(JA)
 本発明は高い酸化安定性と高い生体吸収性を兼ね備えた、水溶性賦形剤を含むマトリックス中に、還元型補酵素Q10を含有する油性成分がドメインを形成して多分散している、還元型補酵素Q10を含有する粒子状組成物、その製造方法、およびその安定化方法を提供する。また該組成物を含む食品、栄養機能食品、特定保健用食品、栄養補助剤、栄養剤、動物薬、飲料、飼料、ペットフード、化粧品、医薬品、治療薬、予防薬等を提供する。
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