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1. WO2007148344 - PROCESS FOR THE PREPARATION OF OLMESARTAN MEDOXOMIL

Publication Number WO/2007/148344
Publication Date 27.12.2007
International Application No. PCT/IN2007/000238
International Filing Date 15.06.2007
IPC
C07D 405/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14containing three or more hetero rings
CPC
C07D 405/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14containing three or more hetero rings
Applicants
  • MATRIX LABORATORIES LIMITED [IN]/[IN] (AllExceptUS)
  • RAMANJANEYULU, Gorantla, Seeta [IN]/[IN] (UsOnly)
  • MOHAN, Bandari [IN]/[IN] (UsOnly)
  • RAY, Purna, Chandra [IN]/[IN] (UsOnly)
  • SETHI, Madhuresh, Kumar [IN]/[IN] (UsOnly)
  • RAWAT, Vijendra, Singh [IN]/[IN] (UsOnly)
  • KRISHNA, Yerramalla, Raja [IN]/[IN] (UsOnly)
  • LAKSHMINARAYANA, Vemula [IN]/[IN] (UsOnly)
  • SRINIVAS, Mamidi [IN]/[IN] (UsOnly)
Inventors
  • RAMANJANEYULU, Gorantla, Seeta
  • MOHAN, Bandari
  • RAY, Purna, Chandra
  • SETHI, Madhuresh, Kumar
  • RAWAT, Vijendra, Singh
  • KRISHNA, Yerramalla, Raja
  • LAKSHMINARAYANA, Vemula
  • SRINIVAS, Mamidi
Agents
  • KAUSHIK, Geetesh
Priority Data
1046/CHE/200619.06.2006IN
2427/CHE/200627.12.2006IN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR THE PREPARATION OF OLMESARTAN MEDOXOMIL
(FR) PROCÉDÉ DE PRÉPARATION D'OLMÉSARTAN MÉDOXOMIL
Abstract
(EN)
The present invention provides a process for the preparation of Olmesartan medoxomil by condensing the ethyl 4-(1-hydroxy-l-methylethyl)-2-propylimidazole-5-carboxylate with 4-[2-(trityl tetrazol-5-yl) phenyl] benzyl bromide to obtain ethyl 4-(1-hydroxy-1-methyl ethyl)-2-propyl-1-{4-[2-(trityltetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate and then hydrolyzing ethyl 4-(1-hydroxy-1-methyl ethyl)-2-propyl-1-{4-[2-(trityl tetrazol-5-yl) phenyl] phenyl} methyl imidazole-5-carboxylate to obtain trityl Olmesartan dihydrate followed by reacting trityl Olmesartan dihydrate with 4-chloromethyl-5-methyl-2-oxo-1,3-dioxolene to obtain trityl Olmesartan medoxomil and then deprotecting trityl Olmesartan medoxomil to obtain Olmesartan medoxomil.
(FR)
La présente invention concerne un procédé de préparation d'olmésartan médoxomil par condensation d'éthyle 4-(1-hydroxy-l-méthyléthyle)-2-propylimidazole-5-carboxylate avec du bromure de benzyle 4-[2-(trityle tétrazole-5-yle)phényle] pour obtenir de l'éthyle 4-(1-hydroxy-1-méthyle éthyle)-2-propyle-1-{4-[2-(trityltétrazole-5-yle)phényle]phényle}méthylimidazole-5-carboxylate, puis par hydrolyse de l'éthyle 4-(1-hydroxy-1-méthyle éthyle)-2-propyle-1-{4-[2-(trityletétrazole-5-yle)phényle]phényle}méthylimidazole-5-carboxylate pour obtenir du trityle de dihydrate d'olmésartan, suivie par la mise en réaction du trityle de dihydrate d'olmésartan avec du 4-chlorométhyle-5-méthyle-2-oxo-1,3-dioxolène pour obtenir du trityle d'olmésartan médoxomile, puis par la déprotection du trityle d'olmésartan médoxomil pour obtenir de l'olmésartan médoxomil.
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