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1. WO2007148064 - PTERIDINE DERIVATIVES AND THEIR USE AS CATHESPIN INHIBITORS

Publication Number WO/2007/148064
Publication Date 27.12.2007
International Application No. PCT/GB2007/002269
International Filing Date 20.06.2007
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
C07D 487/04 (2006.01)
A61K 31/519 (2006.01)
CPC
C07D 475/06
Applicants
  • ASTRAZENECA AB [SE/SE]; S-151 85 Södertälje, SE (AllExceptUS)
  • ASTRAZENECA UK LIMITED [GB/GB]; 15 Stanhope Gate London Greater London W1K 1LN, GB (MG)
  • HEALD, Robert, Andrew [GB/GB]; GB (UsOnly)
  • MORLEY, Andrew, David [GB/GB]; GB (UsOnly)
Inventors
  • HEALD, Robert, Andrew; GB
  • MORLEY, Andrew, David; GB
Agents
  • GLOBAL INTELLECTUAL PROPERTY; AstraZeneca AB S-151 85 Södertälje, SE
Priority Data
60/816,15723.06.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PTERIDINE DERIVATIVES AND THEIR USE AS CATHESPIN INHIBITORS
(FR) DÉRIVÉS DE PTERIDINE ET LEURS UTILISATIONS COMME INHIBITEURS DE LA CATHEPSINE
Abstract
(EN)
The present invention relates to compounds and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases S, K, F, L and B. Of particular interest are diseases associated with Cathepsin K.
(FR)
La présente invention concerne des composés et des compositions pour traiter des maladies associées à une activité cystéine protéase. Les composés sont des inhibiteurs réversibles des cystéine protéases S, K, F, L et B. Les maladies associées à la Cathepsine K sont d'un intérêt particulier.
Latest bibliographic data on file with the International Bureau