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1. WO2007147838 - RADIOLABELLED LIGAND FOR THE GLYCINE 1 TRANSPORTER

Publication Number WO/2007/147838
Publication Date 27.12.2007
International Application No. PCT/EP2007/056117
International Filing Date 20.06.2007
IPC
C07B 59/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
59Introduction of isotopes of elements into organic compounds
A61K 51/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
CPC
C07B 59/001
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
59Introduction of isotopes of elements into organic compounds ; ; Labelled organic compounds per se
001Acyclic or carbocyclic compounds
Applicants
  • GLAXO GROUP LIMITED [GB]/[GB] (AllExceptUS)
  • GENTILE, Gabriella [IT]/[IT] (UsOnly)
  • HERDON, Hugh, Jonathan [GB]/[GB] (UsOnly)
  • PASSCHIER, Johannes [NL]/[GB] (UsOnly)
  • PORTER, Roderick, Alan [GB]/[GB] (UsOnly)
Inventors
  • GENTILE, Gabriella
  • HERDON, Hugh, Jonathan
  • PASSCHIER, Johannes
  • PORTER, Roderick, Alan
Agents
  • KONDO, Rie
Priority Data
0612435.822.06.2006GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) RADIOLABELLED LIGAND FOR THE GLYCINE 1 TRANSPORTER
(FR) LIGAND RADIOMARQUÉ POUR UN TRANSPORTEUR DE GLYCINE 1
Abstract
(EN)
Compounds of formula (I) and salts and solvates thereof, which are radiolabeled ligands for the glycine 1 transporter, are provided: wherein R1 is a radiolabeled group incorporating or consisting of a radionuclide selected from 3H, 11C, 14C, 13N, 15O, 76Br, 18F, 123I, 125I, 131 I, 75Br, 76Br, 77Br and 82Br. Use of the compounds for the labelling and diagnostic imaging of the glycine 1 transporter functionality is disclosed.
(FR)
L'invention concerne des composés représentés par la formule (I) et les sels et solvates de ceux-ci, qui sont des ligands radiomarqués pour le transporteur de glycine 1 : formule dans laquelle R1 est un groupe radiomarqué incorporant ou consistant en un radionucléide choisi parmi 3H, 11C, 14C, 13N, 15O, 76Br, 18F, 123I, 125I, 131I, 75Br, 76Br, 77Br et 82Br. L'invention concerne également l'utilisation des composés pour le marquage et l'imagerie de diagnostic de la fonctionnalité de transporteur de glycine 1.
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