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1. WO2007147574 - SULFONAMIDO-MACROCYCLES AS TIE2 INHIBITORS AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME

Publication Number WO/2007/147574
Publication Date 27.12.2007
International Application No. PCT/EP2007/005419
International Filing Date 15.06.2007
IPC
C07D 513/08 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
513Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/, C07D477/232
02in which the condensed system contains two hetero rings
08Bridged systems
A61K 31/529 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
529forming part of bridged ring systems
A61P 33/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
33Antiparasitic agents
CPC
A61P 33/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
33Antiparasitic agents
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
C07D 513/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
513Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
02in which the condensed system contains two hetero rings
08Bridged systems
Applicants
  • BAYER SCHERING PHARMA AKTIENGESELLSCHAFT [DE]/[DE] (AllExceptUS)
  • HARTUNG, Ingo [DE]/[DE] (UsOnly)
  • KETTSCHAU, Georg [DE]/[DE] (UsOnly)
  • BRIEM, Hans [DE]/[DE] (UsOnly)
  • LUECKING, Ulrich [DE]/[DE] (UsOnly)
  • SCHAEFER, Martina [DE]/[DE] (UsOnly)
  • LIENAU, Philip [DE]/[DE] (UsOnly)
  • BOEMER, Ulf [DE]/[DE] (UsOnly)
  • THIERAUCH, Karl-Heinz [DE]/[DE] (UsOnly)
Inventors
  • HARTUNG, Ingo
  • KETTSCHAU, Georg
  • BRIEM, Hans
  • LUECKING, Ulrich
  • SCHAEFER, Martina
  • LIENAU, Philip
  • BOEMER, Ulf
  • THIERAUCH, Karl-Heinz
Priority Data
06090115.421.06.2006EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SULFONAMIDO-MACROCYCLES AS TIE2 INHIBITORS AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME
(FR) UTILISATION DE MACROCYCLES SULFONAMIDES ET DE SELS DE CES DERNIERS EN TANT QU'INHIBITEURS DE TIE2, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, ET PROCÉDÉS DE PRÉPARATION ET D'UTILISATION ASSOCIÉS
Abstract
(EN)
The invention relates to sulfonamido-macrocycles according to the general formula (I): in which R1, R2, R4, R5, R6, A, B, C, L, X, Y, Z, n, and m are as defined in the claims, and salts, N-oxides, or solvates thereof, to pharmaceutical compositions comprising said sulfonamido-macrocycles, to methods of preparing said sulfonamido- macrocycles as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with Tie2 signalling.
(FR)
L'invention concerne des macrocycles sulfonamides représentés par la formule générale (I), dans laquelle R1, R2, R4, R5, R6, A, B, C, L, X, Y, Z, n et m sont tels que définis dans les revendications, ainsi que des sels, des N-oxydes ou des solvates de ceux-ci. L'invention a également trait à des compositions pharmaceutiques contenant lesdits macrocycles sulfonamides, à des procédés de préparation desdits macrocycles sulfonamides, ainsi qu'à leur utilisation pour produire une composition pharmaceutique destinée à traiter des maladies induites par un dérèglement de la croissance vasculaire ou des maladies qui s'accompagnent d'un dérèglement de la croissance vasculaire, lesdits composés faisant efficacement obstacle à la signalisation de Tie2.
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