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1. WO2007147554 - IMPROVED CROMATOGRAPHY PROCESS FOR RECOVERING A SUBSTANCE OR A GROUP OF SUBSTANCES FROM A MIXTURE

Publication Number WO/2007/147554
Publication Date 27.12.2007
International Application No. PCT/EP2007/005379
International Filing Date 19.06.2007
Chapter 2 Demand Filed 22.04.2008
IPC
B01D 15/16 2006.1
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
08Selective adsorption, e.g. chromatography
10characterised by constructional or operational features
16relating to the conditioning of the fluid carrier
B01D 15/40 2006.1
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
08Selective adsorption, e.g. chromatography
26characterised by the separation mechanism
40using supercritical fluid as mobile phase or eluent
G01N 30/28 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
02Column chromatography
26Conditioning of the fluid carrier; Flow patterns
28Control of physical parameters of the fluid carrier
CPC
B01D 15/161
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents
08Selective adsorption, e.g. chromatography
10characterised by constructional or operational features
16relating to the conditioning of the fluid carrier
161Temperature conditioning
B01D 15/163
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents
08Selective adsorption, e.g. chromatography
10characterised by constructional or operational features
16relating to the conditioning of the fluid carrier
163Pressure or speed conditioning
B01D 15/40
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents
08Selective adsorption, e.g. chromatography
26characterised by the separation mechanism
40using supercritical fluid as mobile phase or eluent
B01J 20/286
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
20Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
281Sorbents specially adapted for preparative, analytical or investigative chromatography
286Phases chemically bonded to a substrate, e.g. to silica or to polymers
G01N 2030/3076
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography ; or field flow fractionation;
02Column chromatography
26Conditioning of the fluid carrier; Flow patterns
28Control of physical parameters of the fluid carrier
30of temperature
3076using specially adapted T(t) profile
G01N 30/02
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography ; or field flow fractionation;
02Column chromatography
Applicants
  • K.D. PHARMA BEXBACH GMBH [DE]/[DE] (AllExceptUS)
  • KRUMBHOLZ, Rudolf [DE]/[DE] (UsOnly)
  • LEMBKE, Peter [DE]/[DE] (UsOnly)
  • SCHIRRA, Norbert [DE]/[DE] (UsOnly)
Inventors
  • KRUMBHOLZ, Rudolf
  • LEMBKE, Peter
  • SCHIRRA, Norbert
Agents
  • GERVASI, Gemma
Priority Data
06115656.819.06.2006EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) IMPROVED CROMATOGRAPHY PROCESS FOR RECOVERING A SUBSTANCE OR A GROUP OF SUBSTANCES FROM A MIXTURE
(FR) PROCÉDÉ AMÉLIORÉ SERVANT À RÉCUPÉRER UNE SUBSTANCE OU UN GROUPE DE SUBSTANCES À PARTIR D'UN MÉLANGE
Abstract
(EN) Method for improving the performance of a preparative batchwise Super Critical Fluid Chromatographic separation for the recovery of a target fatty acid or derivative thereof, or of a group of target fatty acids or of derivatives thereof from a mixture, characterized in that the said Super Critical Fluid Chromatographic separation employs a chromatographic column charged with a stationary phase chosen from the group consisting of aluminium oxide or aluminium oxides, titanium oxide or titanium oxides, silica gel or silica gels, amino propyl modified silica gels, diol modified silica gels, phenyl modified silica gels and 'reversed phase' phases, the former in turn chosen from the group consisting of RP 18, RP8 and RP3, and in that the said Super Critical Fluid Chromatographic Separation further employs a mobile phase chosen from the group consisting of ethylene, propane, ammonia, dinitrogen dioxide and CO2, wherein in the said method, during the run of the said mixture on the chromatographic column, a pressure and/or temperature gradient is applied to the chromatographic column during the elution of the target fatty acid or derivative thereof.
(FR) Procédé servant à améliorer les performances d'une séparation chromatographique en phase supercritique préparative fonctionnant par lots discontinus pour la récupération d'un acide gras cible ou d'un dérivé de celui-ci ou d'un groupe d'acides gras cibles ou de dérivés de ceux-ci à partir d'un mélange, caractérisé en ce que ladite séparation chromatographique en phase supercritique emploie une colonne chromatographique remplie d'une phase stationnaire choisie dans le groupe constitué de l'oxyde d'aluminium ou d'oxydes d'aluminium, de l'oxyde de titane ou d'oxydes de titane, du gel de silice ou de gels de silice, de gels de silice modifiés aminopropyle, de gels de silice modifiés par des diols, de gels de silice modifiés phényle et de phases de type 'phases inverses', celles-ci étant à leur tour choisies dans le groupe constitué des phases RP 18, RP8 et RP3, et en ce que ladite séparation chromatographique en phase supercritique emploie en outre une phase mobile choisie dans le groupe constitué de l'éthylène, du propane, de l'ammoniac, du dioxyde de diazote et du CO2, ledit procédé consistant, au cours du passage dudit mélange sur la colonne chromatographique, à appliquer un gradient de pression et/ou de température à la colonne chromatographique au cours de l'élution de l'acide gras cible ou du dérivé de celui-ci.
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