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1. WO2007147370 - PSEUDOCERAMIDES AND PHARMACEUTICAL AND/OR COSMETIC COMPOSITIONS DESIGNED FOR ADMINISTRATION TO THE SKIN CONTAINING THE SAME

Publication Number WO/2007/147370
Publication Date 27.12.2007
International Application No. PCT/CZ2007/000057
International Filing Date 19.06.2007
Chapter 2 Demand Filed 14.04.2008
IPC
A61K 31/164 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
164of a carboxylic acid with an aminoalcohol, e.g. ceramides
C07C 233/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
01having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
45having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
46with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
47having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
A61P 17/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
CPC
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
C07C 233/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
01having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
45having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
46with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
47having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
Applicants
  • UNIVERZITA KARLOVA V PRAZE Farmaceuticka Fakulta V Hradci Kralové [CZ]/[CZ] (AllExceptUS)
  • VAVROVA, Katerina [CZ]/[CZ] (UsOnly)
  • DOLEZAL, Pavel [CZ]/[CZ] (UsOnly)
  • HRABALEK, Alexandr [CZ]/[CZ] (UsOnly)
Inventors
  • VAVROVA, Katerina
  • DOLEZAL, Pavel
  • HRABALEK, Alexandr
Agents
  • GUTTMANN, Michal
Priority Data
PV 2006-41323.06.2006CZ
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PSEUDOCERAMIDES AND PHARMACEUTICAL AND/OR COSMETIC COMPOSITIONS DESIGNED FOR ADMINISTRATION TO THE SKIN CONTAINING THE SAME
(FR) PSEUDOCÉRAMIDES ET COMPOSITIONS PHARMACEUTIQUES ET/OU COSMÉTIQUES LES CONTENANT, DESTINÉS À UNE ADMINISTRATION CUTANÉE
Abstract
(EN)
Pharmaceutical and/or cosmetic compositions designed for application to the human or animal skin, comprising a pseudoceramide of general formula (I), wherein R1 is an alkyl with the chain length of from C12 to C20; R2 is an alkyl or alkenyl with the chain length of from C15 to C29, the minimal number of carbons in the molecule being 36, in amounts of from 0.01 to 20 weight %, based on the total weight of the composition, in a pharmaceutically acceptable vehicle. The compositions are designed for relipidization of the skin as well as for supplementary treatment of skin diseases associated with lowered lipid content and increased skin permeability. They can be used for treatment of damaged, dry or ageing skin and skin adnexa or for prevention of skin damage and skin adnexa. Novel pseudoceramides of general formula (II) are also described.
(FR)
La présente invention concerne des compositions pharmaceutiques et/ou cosmétiques destinées à une application à la peau humaine ou animale, comprenant un pseudocéramide de formule générale (I), R1 étant un alkyle d'une longueur de chaîne comprise entre C12 et C20; R2 étant un alkyle ou un alcényle d'une longueur de chaîne comprise entre C15 et C29, le nombre minimal de carbones dans la molécule étant de 36, dans des quantités comprises entre 0,01 et 20 % en poids, sur la base du poids total de la composition, dans un excipient pharmaceutiquement acceptable. Lesdites compositions sont conçues à des fins de relipidisation cutanée ainsi qu'en tant que traitement complémentaire des maladies cutanées associées à une teneur en lipides réduite et à une perméabilité cutanée accrue. Lesdites compositions peuvent être utilisées pour le traitement de la peau lésée, sèche ou vieillissante et des annexes cutanées, ainsi que pour la prévention de lésions cutanées et des annexes cutanées. L'invention concerne également des pseudocéramides de formule générale (II).
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