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1. WO2007147098 - IDENTIFICATION AND USE OF NON-PEPTIDE ANALOGS OF RNAIII-INHIBITING PEPTIDE FOR THE TREATMENT OF STAPHYLOCOCCAL INFECTIONS

Publication Number WO/2007/147098
Publication Date 21.12.2007
International Application No. PCT/US2007/071303
International Filing Date 15.06.2007
IPC
A01N 43/08 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
02having rings with one or more oxygen or sulfur atoms as the only ring hetero atom
04with one hetero atom
06five-membered rings
08with oxygen as the ring hetero atom
A01N 25/00 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
25Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
CPC
A61K 31/7004
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7004Monosaccharides having only carbon, hydrogen and oxygen atoms
A61K 31/7024
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7024Esters of saccharides
A61K 9/0019
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
G16B 35/00
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
35ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
G16C 20/60
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
CCOMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
20Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
60In silico combinatorial chemistry
Applicants
  • TUFTS UNIVERSITY [US]/[US] (AllExceptUS)
  • CASE WESTERN RESERVE UNIVERSITY [US]/[US] (AllExceptUS)
  • BALABAN, Naomi [US]/[US] (UsOnly)
  • SHOHAM, Menachem [US]/[US] (UsOnly)
Inventors
  • BALABAN, Naomi
  • SHOHAM, Menachem
Agents
  • KELBER, Steven
Priority Data
60/814,06716.06.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) IDENTIFICATION AND USE OF NON-PEPTIDE ANALOGS OF RNAIII-INHIBITING PEPTIDE FOR THE TREATMENT OF STAPHYLOCOCCAL INFECTIONS
(FR) IDENTIFICATION ET UTILISATION D'ANALOGUES NON PEPTIDIQUES DE PEPTIDES INHIBANT L'ARNIII POUR LE TRAITEMENT D'INFECTIONS PAR LE STAPHYLOCOQUE
Abstract
(EN)
RNAIII inhibiting peptide (RIP) has been established as an effective inhibitor of staphylococcal infections. Non-peptide small molecule analogs based on a pharmacophore conforming to the putative atomic structure of RIP, can be identified by computer screening of that pharmacophore against established libraries of known small molecules other than peptides. One such identified structural analog is hamamelitannin. When tested for effective inhibition of staphylococcal infections, hamamelitannin demonstrated inhibition similar to that exhibited by RIP. Other analogs can be identified and similarly used.
(FR)
La présente invention concerne un peptide inhibant l'ARNIII (PIA) qui a été reconnu comme étant un inhibiteur efficace d'infections par le staphylocoque. De petites molécules non peptidiques analogues basées sur un pharmacophore conforme à la structure atomique supposée du PIA, peuvent être identifiées par un criblage automatisé de ce pharmacophore par rapport à des bibliothèques établies de petites molécules connues, autres que des peptides. L'un de ces analogues structuraux identifiés est l'hamamélitannine. Testée pour son efficacité d'inhibition des infections par le staphylocoque, l'hamamélitannine a fait preuve d'une capacité d'inhibition semblable à celle que présente le PIA. D'autres analogues peuvent être identifiés et utilisés de manière similaire.
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