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1. (WO2007147079) RARE CELL ANALYSIS USING SAMPLE SPLITTING AND DNA TAGS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2007/147079 International Application No.: PCT/US2007/071256
Publication Date: 21.12.2007 International Filing Date: 14.06.2007
IPC:
C12Q 1/68 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
SHOEMAKER, Daniel [US/US]; US (UsOnly)
FUCHS, Martin [DK/US]; US (UsOnly)
KRUEGER, Neil, X. [US/US]; US (UsOnly)
TONER, Mehmet [US/US]; US (UsOnly)
GRAY, Darren [US/US]; US (UsOnly)
KAPUR, Ravi [US/US]; US (UsOnly)
WANG, Zihua [US/US]; US (UsOnly)
LIVING MICROSYSTEMS, INC. [US/US]; 480 Arsenal Street, Suite 130 Watertown, MA 02472, US (AllExceptUS)
CELLPOINT DIAGNOSTICS, INC. [US/US]; 505 Coast Blvd. South, Suite 406 La Jolla, CA 92037, US (AllExceptUS)
THE GENERAL HOSPITAL CORPORATION [US/US]; 55 Fruit Street Boston, MA 02114, US (AllExceptUS)
Inventors:
SHOEMAKER, Daniel; US
FUCHS, Martin; US
KRUEGER, Neil, X.; US
TONER, Mehmet; US
GRAY, Darren; US
KAPUR, Ravi; US
WANG, Zihua; US
Agent:
LIETO, Louis ; Wilson Sonsini Goodrich & Rosati 650 Page Mill Road Palo Alto, CA 94304-1050, US
Priority Data:
60/804,81914.06.2006US
60/820,77828.07.2006US
Title (EN) RARE CELL ANALYSIS USING SAMPLE SPLITTING AND DNA TAGS
(FR) analyse de celluleS rareS avec recours au fractionnement d'échantillons et à des marqueurs d'adn
Abstract:
(EN) The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample.
(FR) La présente invention propose des systèmes, des appareils et des procédés pour détecter la présence de cellules foetales lorsqu'elles sont mélangées avec une population de cellules maternelles dans un échantillon afin de tester des anomalies foetales, par exemple l'aneuploïdie. La présente invention recourt au marquage par différents marqueurs des régions de l'ADN génomique de chaque cellule dans ledit échantillon mélangé, chaque marqueur étant spécifique à chaque cellule, et à la quantification des régions marquées de l'ADN génomique de chaque cellule dans l'échantillon mélangé. Plus particulièrement, l'invention recourt à la quantification des polymorphismes de l'ADN marqué de chaque cellule dans l'échantillon mélangé.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)