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1. WO2007146683 - OPHTHALMIC COMPOSITIONS COMPRISING A BRANCHED, GLYCEROL MONOALKYL COMPOUND AND A FATTY ACID MONOESTER

Publication Number WO/2007/146683
Publication Date 21.12.2007
International Application No. PCT/US2007/070461
International Filing Date 06.06.2007
IPC
A61K 9/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
08Solutions
A61L 12/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
12Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
08using chemical substances
14Organic compounds not covered by groups A61L12/10 or A61L12/12100
A61L 2/18 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
16using chemical substances
18Liquid substances
CPC
A61K 9/0048
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0048Eye, e.g. artificial tears
A61L 12/141
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
12Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
08using chemical substances
14Organic compounds not covered by groups A61L12/10 or A61L12/12
141Biguanides, e.g. chlorhexidine
A61L 12/142
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
12Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
08using chemical substances
14Organic compounds not covered by groups A61L12/10 or A61L12/12
141Biguanides, e.g. chlorhexidine
142Polymeric biguanides
A61L 12/143
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
12Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
08using chemical substances
14Organic compounds not covered by groups A61L12/10 or A61L12/12
143Quaternary ammonium compounds
A61L 12/145
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
12Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
08using chemical substances
14Organic compounds not covered by groups A61L12/10 or A61L12/12
143Quaternary ammonium compounds
145Polymeric quaternary ammonium compounds
C11D 1/667
CCHEMISTRY; METALLURGY
11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
DDETERGENT COMPOSITIONS
1Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
66Non-ionic compounds
667Neutral esters, e.g. sorbitan esters; see also C11D1/74 and C11D1/78
Applicants
  • BAUSCH & LOMB INCORPORATED [US]/[US] (AllExceptUS)
  • BURKE, Susan, E. [US]/[US] (UsOnly)
  • PHILLIPS, Eric [US]/[US] (UsOnly)
  • ZHAO, Fang [US]/[US] (UsOnly)
  • BARNIAK, Vicki, L. [US]/[US] (UsOnly)
  • SALAMONE, Joseph, C. [US]/[US] (UsOnly)
Inventors
  • BURKE, Susan, E.
  • PHILLIPS, Eric
  • ZHAO, Fang
  • BARNIAK, Vicki, L.
  • SALAMONE, Joseph, C.
Agents
  • BARRERA, Joseph
Priority Data
11/691,12526.03.2007US
60/811,82808.06.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) OPHTHALMIC COMPOSITIONS COMPRISING A BRANCHED, GLYCEROL MONOALKYL COMPOUND AND A FATTY ACID MONOESTER
(FR) COMPOSITIONS OPHTALMIQUES COMPRENANT UN DÉRIVÉ MONOALKYLIQUE RAMIFIÉ DE GLYCÉROL ET UN MONOESTER D'ACIDE GRAS
Abstract
(EN)
An aqueous ophthalmic composition comprising a branched, glycerol monoalkyl compound and a fatty acid monoester. The fatty acid monoester comprises an aliphatic fatty acid portion having six to fourteen carbon atoms and an aliphatic hydroxyl portion. The composition will also have an osmolality in a range from 200 mOsmol/kg to 400 mOsmol/kg. The invention is also directed to a method of inhibiting the formation of foam in an aqueous ophthalmic composition that includes a surfactant as well as to a method of enhancing the biocidal efficacy of an aqueous ophthalmic composition containing a fatty acid monoester.
(FR)
La présente invention concerne une composition ophtalmique aqueuse qui comprend un dérivé monoalkylique ramifié de glycérol et un monoester d'acide gras. Le monoester d'acide gras comprend une portion acide gras aliphatique comportant entre six et quatorze atomes de carbone et une portion hydroxy aliphatique. La composition présente également une osmolalité comprise entre 200 mOsmol/kg et 400 mOsmol/kg. La présente invention concerne en outre une méthode d'inhibition de la formation de mousse dans une composition ophtalmique aqueuse qui inclut un tensioactif, ainsi qu'une méthode d'amplification de l'efficacité biocide d'une composition ophtalmique aqueuse contenant un monoester d'acides gras.
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