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1. WO2007146188 - ANTI-LEUKOCYTE RECRUITMENT THERAPY FOR THE TREATMENT OF SEIZURES AND EPILEPSY

Publication Number WO/2007/146188
Publication Date 21.12.2007
International Application No. PCT/US2007/013624
International Filing Date 06.06.2007
IPC
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
CPC
A61K 39/3955
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
39533against materials from animals
3955against proteinaceous materials, e.g. enzymes, hormones, lymphokines
C07K 16/2821
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2803against the immunoglobulin superfamily
2821against ICAM molecules, e.g. CD50, CD54, CD102
C07K 16/2836
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2803against the immunoglobulin superfamily
2836against CD106
C07K 16/2842
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2839against the integrin superfamily
2842against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
C07K 16/2845
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2839against the integrin superfamily
2845against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
C07K 16/2854
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2851against the lectin superfamily, e.g. CD23, CD72
2854against selectins, e.g. CD62
Applicants
  • THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY [US]/[US] (AllExceptUS)
  • DEPARTMENT OF VETERANS AFFAIRS [US]/[US] (AllExceptUS)
  • FABENE, Paolo [IT]/[IT]
  • BUTCHER, Eugene C. [US]/[US] (UsOnly)
  • CONSTANTIN, Gabriela [IT]/[IT]
Inventors
  • FABENE, Paolo
  • BUTCHER, Eugene C.
  • CONSTANTIN, Gabriela
Agents
  • SHERWOOD, Pamela J.
Priority Data
60/811,87307.06.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANTI-LEUKOCYTE RECRUITMENT THERAPY FOR THE TREATMENT OF SEIZURES AND EPILEPSY
(FR) THÉRAPIE DE RECRUTEMENT ANTI-LEUCOCYTAIRE POUR LE TRAITEMENT DE CRISES ÉPILEPTIQUES ET DE L'ÉPILEPSIE
Abstract
(EN)
Methods are provided for the prevention and treatment of seizures and epilepsy. It is shown herein that leukocyte recruitment plays a key role in the pathogenesis of epilepsy. Treatment with an agent that inhibits leukocyte recruitment has therapeutic and preventative effects in blocking recurrent seizures and epilepsy.
(FR)
L'invention concerne des méthodes pour prévenir et traiter des crises épileptiques et l'épilepsie. Il est montré ici que le recrutement de leucocytes joue un rôle clé dans la pathogénie de l'épilepsie. Le traitement par un agent qui inhibe le recrutement de leucocytes a des effets thérapeutiques et préventifs en bloquant des crises épileptiques périodiques et l'épilepsie.
Also published as
Latest bibliographic data on file with the International Bureau