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1. WO2007146174 - ADMINISTRATION OF DOPA PRECURSORS WITH SOURCES OF DOPA TO EFFECTUATE OPTIMAL CATECHOLAMINE NEUROTRANSMITTER OUTCOMES

Publication Number WO/2007/146174
Publication Date 21.12.2007
International Application No. PCT/US2007/013596
International Filing Date 08.06.2007
IPC
A01N 33/02 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
33Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
02Amines; Quaternary ammonium compounds
CPC
A61K 31/137
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines
135having aromatic rings ; , e.g. ketamine, nortriptyline
137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine ; or methadone
A61K 31/198
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
197the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198Alpha-aminoacids, e.g. alanine, edetic acids [EDTA],
A61K 31/205
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
205Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
Applicants
  • NEURORESEARCH, INC. [US]/[US] (AllExceptUS)
  • HINZ, Martin, C. [US]/[US] (UsOnly)
Inventors
  • HINZ, Martin, C.
Agents
  • VOIGT II, Edwin, E.
Priority Data
11/759,73207.06.2007US
60/811,84408.06.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ADMINISTRATION OF DOPA PRECURSORS WITH SOURCES OF DOPA TO EFFECTUATE OPTIMAL CATECHOLAMINE NEUROTRANSMITTER OUTCOMES
(FR) ADMINISTRATION DE PRÉCURSEURS DE DOPA COMBINÉS À DES SOURCES DE DOPA EN VUE D'OBTENIR DES RÉSULTATS OPTIMAUX AVEC LES NEUROTRANSMETTEURS DE CATÉCHOLAMINE
Abstract
(EN)
A method of treating neurotransmitter dysfunction in a patient by optimizing catecholamine levels by administration of L-3,4-dihydroxyphenylalanine (L-Dopa or Dopa) precurors in combination with a source of L-Dopa. The dopa precursor is preferably administered in such quantities such that the amount of dopa from the dopa precursors does not fluctuate and affect outcomes in the synthesis of dopamine from dopa administration. The dopa precursor source is preferably tyrosine, but may alternatively be phenylalanine, N-acetyl- tyrosine, any active isomer thereof, or any other dopa precursor. The source of L-Dopa may include any natural or synthetic source, including, but not limited to, Mucuna pruriels.
(FR)
La présente invention concerne un procédé de traitement du dysfonctionnement des neurotransmetteurs chez un patient par l'optimisation des niveaux de catécholamine grâce à une administration de précurseurs de L-3,4-dihydroxyphénylalanine (L-Dopa ou Dopa) combinés à une source de L-Dopa. Le précurseur de dopa est de préférence administré dans des quantités telles que la quantité de dopa provenant des précurseurs de dopa ne fluctue pas et ne modifie pas les résultats de la synthèse de dopamine découlant de l'administration de dopa. La source de précurseurs de dopa est de préférence de la tyrosine, mais peut être dans une variante de la phénylalanine, de la N-acétyl-tyrosine, n'importe quel isomère actif de celle-ci, ou n'importe quel autre précurseur de dopa. La source de L-Dopa peut inclure n'importe quelle source naturelle ou synthétique, incluant, mais sans s'y limiter, Mucuna pruriels.
Also published as
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