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1. WO2007146122 - TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES

Publication Number WO/2007/146122
Publication Date 21.12.2007
International Application No. PCT/US2007/013506
International Filing Date 08.06.2007
IPC
C07D 471/02 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
C07D 417/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14containing three or more hetero rings
C07D 265/30 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
265Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
281,4-Oxazines; Hydrogenated 1,4-oxazines
30not condensed with other rings
A61K 31/54 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
54having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame
CPC
A61K 31/496
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
A61K 31/55
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
06Antimigraine agents
A61P 25/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
16Anti-Parkinson drugs
A61P 25/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Applicants
  • NEUROGEN CORPORATION [US]/[US] (AllExceptUS)
  • XU, Yuelian [CN]/[US] (UsOnly)
  • GAO, Yang [CN]/[US] (UsOnly)
  • XIE, Linghong [US]/[US] (UsOnly)
Inventors
  • XU, Yuelian
  • GAO, Yang
  • XIE, Linghong
Agents
  • RUSSETT, Mark, D.
Priority Data
11/759,92907.06.2007US
60/804,30509.06.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES
(FR) TÉTRAHYDROPYRIDO[3,4-D]PYRIMIDINES ET ANALOGUES ASSOCIÉS
Abstract
(EN)
Tetrahydropyrido[3,4-d]pyrimidines and related analogues are provided, of the formula (I) in which variables are as described herein, as are methods for their preparation and use. Such compounds may generally be used to modulate ligand binding to histamine H3 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and therapeutic methods are provided, as are methods for using such ligands for detecting histamine H3 receptors (e.g., receptor localization studies).
(FR)
La présente invention concerne des tétrahydropyrido[3,4-D]pyrimidines et leurs analogues, représentées par la formule : FORMULE (I), les variables étant telles que décrites ici, de même que des procédés permettant leur préparation et leur utilisation. De tels composés peuvent d'une manière générale être utilisés pour moduler la liaison de ligands aux récepteurs de l'histamine H3 in vivo ou in vitro, et ils se révèlent particulièrement utiles pour le traitement d'une variété de troubles chez les êtres humains, les animaux de compagnie, et les animaux d'élevage. L'invention concerne également des compositions pharmaceutiques et des procédés thérapeutiques, lesdits procédés permettant d'utiliser lesdits ligands en vue de la détection des récepteurs de l'histamine H3 (par exemple, des études de localisation des récepteurs).
Also published as
Latest bibliographic data on file with the International Bureau