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1. WO2007146104 - SUBSTRATES AND INHIBITORS OF ANTIPLASMIN CLEAVING ENZYME AND METHODS OF USE

Publication Number WO/2007/146104
Publication Date 21.12.2007
International Application No. PCT/US2007/013480
International Filing Date 06.06.2007
Chapter 2 Demand Filed 06.06.2007
IPC
G01N 33/53 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 47/60
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
56the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
59obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
60the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
A61P 7/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
A61P 7/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
A61P 9/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applicants
  • MCKEE, Patrick, A. [US]/[US]
  • LEE, Kyung, N. [US]/[US]
  • JACKSON, Kenneth, W. [US]/[US]
  • CHRISTIANSEN, Victoria, J.
Inventors
  • MCKEE, Patrick, A.
  • LEE, Kyung, N.
  • JACKSON, Kenneth, W.
  • CHRISTIANSEN, Victoria, J.
Agents
  • CORBETT, Christopher, W.
Priority Data
60/811,56807.06.2006US
60/836,36508.08.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SUBSTRATES AND INHIBITORS OF ANTIPLASMIN CLEAVING ENZYME AND METHODS OF USE
(FR) SUBSTRATS ET INHIBITEURS DE L'ENZYME DE CLIVAGE DE L'ANTIPLASMINE ET PROCÉDÉS D'UTILISATION
Abstract
(EN)
The present invention is directed toward inhibitors of antiplasmin cleaving enzyme for use in various therapies related to fibrin and α2-antiplasmin, and to substrates of APCE, which may be used, for example, in screening methods for identifying such inhibitors. The present invention is further directed to methods of treating or inhibiting atherosclerosis and thrombus disorders by altering the rations of types of plasma α2-antiplasmin.
(FR)
La présente invention concerne des inhibiteurs de l'enzyme de clivage de l'antiplasmine (ECAP) destinés à être utilisés dans diverses thérapies associées à la fibrine et à l'antiplasmine α2, ainsi que des substrats d'ECAP, qui peuvent être utilisés, par exemple, dans des procédés de criblage destinés à l'identification desdits inhibiteurs. La présente invention concerne en outre des procédés de traitement ou d'inhibition de l'athérosclérose et de troubles thrombotiques grâce à une modification des rapports des types d'antiplasmine α2 plasmatique.
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