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1. WO2007145934 - COMBINATION OF INSULIN AND ASCORBATE TO ENHANCE WOUND HEALING

Publication Number WO/2007/145934
Publication Date 21.12.2007
International Application No. PCT/US2007/013219
International Filing Date 05.06.2007
IPC
A61K 38/39 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
39Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin
A61K 38/28 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
22Hormones
28Insulins
CPC
A61K 38/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
22Hormones
28Insulins
Applicants
  • UNIVERSITY OF SOUTH FLORIDA [US]/[US] (AllExceptUS)
  • MUSSELMANN, Kurt [DE]/[US] (UsOnly)
  • HASSELL, John, R. [US]/[US] (UsOnly)
  • KANE, Brad [US]/[US] (UsOnly)
  • ALEXANDROU, Bridgette [US]/[US] (UsOnly)
Inventors
  • MUSSELMANN, Kurt
  • HASSELL, John, R.
  • KANE, Brad
  • ALEXANDROU, Bridgette
Agents
  • TONER, Thomas, E.
Priority Data
60/803,94405.06.2006US
60/823,58325.08.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMBINATION OF INSULIN AND ASCORBATE TO ENHANCE WOUND HEALING
(FR) COMBINAISON D'INSULINE ET D'ASCORBATE POUR FAVORISER LA CICATRISATION DE PLAIES
Abstract
(EN)
Provided is a method of stimulating collagen synthesis and proteoglycan (lumican and keratocan) accumulation. Collagenase isolated keratocytes were cultured with or without insulin with or without ascorbate. Insulin stimulates the synthesis of collagen but does not affect the accumulation of lumican and keratocan. Insulin plus ascorbate, however, stimulates the synthesis of collagen and increased the accumulation of these proteoglycans. The accumulation of PGDS, a KSPG that does not interact with collagen, is not affected by ascorbate. Only the collagen made in the presence of ascorbate was pepsin resistant. EDB overrode the effects of ascorbate on pepsin resistance and proteoglycan accumulation.
(FR)
La présente invention concerne un procédé permettant de stimuler la synthèse du collagène et l'accumulation de protéoglycane (lumicane et kératocane). Les kératocytes isolés par la collagénase ont été cultivés avec ou sans insuline et avec ou sans ascorbate. L'insuline stimule la synthèse de collagène mais ne modifie pas l'accumulation de lumicane et de kératocane. L'insuline additionnée d'ascorbate stimule cependant la synthèse de collagène et favorise l'accumulation de ces protéoglycanes. L'accumulation de PGDS, un KSPG qui n'interagit pas avec le collagène, n'est pas modifiée par l'ascorbate. Seul le collagène fabriqué en présence d'ascorbate s'est révélé résistant à la pepsine. L'EDB a annulé les effets de l'ascorbate sur la résistance à la pepsine et l'accumulation de protéoglycane.
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