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1. WO2007145682 - ORAL DTPA FOR RADIONUCLIDE CHELATION

Publication Number WO/2007/145682
Publication Date 21.12.2007
International Application No. PCT/US2007/003985
International Filing Date 14.02.2007
IPC
A61K 31/13 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
A61K 49/20 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
20containing free radicals
A61P 39/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
39General protective or antinoxious agents
04Chelating agents
CPC
A61K 31/198
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
197the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198Alpha-aminoacids, e.g. alanine, edetic acids [EDTA],
A61K 9/4858
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
4841Filling excipients; Inactive ingredients
4858Organic compounds
A61P 39/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
39General protective or antinoxious agents
02Antidotes
A61P 39/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
39General protective or antinoxious agents
04Chelating agents
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applicants
  • SRI INTERNATIONAL [US]/[US] (AllExceptUS)
  • SHANKAR, Gita, Natarajan [US]/[US] (UsOnly)
  • PARISH, Helen, Jaber [US]/[US] (UsOnly)
Inventors
  • SHANKAR, Gita, Natarajan
  • PARISH, Helen, Jaber
Agents
  • OSMAN, Richard
Priority Data
60/774,93517.02.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ORAL DTPA FOR RADIONUCLIDE CHELATION
(FR) DTPA ORAL UTILISÉ POUR UNE CHÉLATION DE RADIONUCLÉIDES
Abstract
(EN)
A composition for oral radionuclide chelation therapy comprises a DTPA chelate selected from Zn-DTPA and Ca-DTPA and a permeation enhancer that preferentially increases jejunal uptake of the DTPA chelate. The composition has a DTPA chelate bioavailability of at least 10% of the chelate when orally administered to a mammal.
(FR)
La présente invention concerne une composition destinée à une thérapie orale par chélation de radionucléides qui contient un chélate de DTPA choisi parmi le Zn-DTPA et le Ca-DTPA ainsi qu'un adjuvant de perméation qui augmente préférentiellement l'assimilation jéjunale du chélate de DTPA. La composition présente une biodisponibilité du chélate de DTPA d'au moins 10 % de l'élément chélaté lorsqu'elle est administrée par voie orale à un mammifère.
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