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1. WO2007145325 - TEST METHOD FOR MALT LYMPHOMA AND KIT THEREFOR

Publication Number WO/2007/145325
Publication Date 21.12.2007
International Application No. PCT/JP2007/062139
International Filing Date 15.06.2007
Chapter 2 Demand Filed 04.04.2008
IPC
C12Q 1/68 2006.01
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12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
C12Q 1/02 2006.01
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12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
02involving viable microorganisms
C12Q 1/42 2006.01
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1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
34involving hydrolase
42involving phosphatase
C12Q 1/44 2006.01
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1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
34involving hydrolase
44involving esterase
CPC
C12Q 1/6886
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1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
C12Q 2600/112
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QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
112Disease subtyping, staging or classification
C12Q 2600/118
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2600Oligonucleotides characterized by their use
118Prognosis of disease development
C12Q 2600/154
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2600Oligonucleotides characterized by their use
154Methylation markers
C12Q 2600/16
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2600Oligonucleotides characterized by their use
16Primer sets for multiplex assays
G01N 2800/56
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
56Staging of a disease; Further complications associated with the disease
Applicants
  • 国立大学法人岡山大学 NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY [JP]/[JP] (AllExceptUS)
  • 岡 剛史 OKA, Takashi [JP]/[JP] (UsOnly)
  • 近藤 孝美 KONDO, Takami [JP]/[JP] (UsOnly)
  • 吉野 正 YOSHINO, Tadashi [JP]/[JP] (UsOnly)
  • 大内田 守 OUCHIDA, Mamoru [JP]/[JP] (UsOnly)
Inventors
  • 岡 剛史 OKA, Takashi
  • 近藤 孝美 KONDO, Takami
  • 吉野 正 YOSHINO, Tadashi
  • 大内田 守 OUCHIDA, Mamoru
Agents
  • 鈴木 俊一郎 SUZUKI, Shunichiro
Priority Data
2006-16781716.06.2006JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) TEST METHOD FOR MALT LYMPHOMA AND KIT THEREFOR
(FR) MÉTHODE ET KIT DE TEST DU LYMPHOME MALT
(JA) MALTリンパ腫の検査方法及びキット
Abstract
(EN)
It is intended to provide a test method for MALT lymphoma for providing genetic diagnosis data which can be used for the diagnosis of MALT lymphoma, identification of disease type, progression of pathological conditions, and prediction of the onset thereof, and a kit for implementing the method. Two or more tumor suppressor genes or cancer-related genes in a sample are selected, particularly two or more genes are selected from the gene group consisting of 11 genes, and the expression level of the selected genes or the state of regulation of gene expression thereof is examined. To be more specific, the gene product is determined, and the expression profile of the gene group is constructed based on the determination results or an early detection/diagnosis with high sensitivity and accuracy is performed based on the examination of regulation of expression by detection of methylation frequency. Data for diagnosing MALT lymphoma or for evaluating the possibility to develop into a disease type requiring therapy, and data for making early detection of development into a disease type with poor prognosis.
(FR)
L'invention concerne une méthode de test du lymphome MALT permettant d'obtenir des données de diagnostic génétique utilisables pour diagnostiquer un lymphome MALT, identifier le type de maladie, suivre l'évolution d'états pathologiques et en prédire l'apparition, ainsi qu'un kit permettant la mise en œuvre de cette méthode. On sélectionne deux ou plusieurs gènes suppresseurs de tumeurs ou gènes apparentés au cancer dans un échantillon, en particulier on sélectionne deux ou plusieurs gènes dans un groupe constitué de 11 gènes, et on examine le niveau d'expression des gènes sélectionnés ou l'état de régulation de leur expression. Plus spécifiquement, on détermine le produit génique et on établit le profil d'expression du groupe de gènes sur la base des résultats de la détermination ou bien on effectue une détection/un diagnostic précoce avec une sensibilité et une précision élevées sur la base de l'examen de la régulation de l'expression en détectant la fréquence de méthylation. On obtient des données permettant de diagnostiquer un lymphome MALT ou d'évaluer la possibilité de développement d'un type de maladie nécessitant un traitement, ainsi que des données permettant la détection précoce de l'évolution vers un type de maladie à pronostic défavorable.
(JA)
 本発明は、MALTリンパ腫の診断および病型の同定、病態の進展、発症の予測に利用できる遺伝子診断データを提供するMALTリンパ腫の検査方法ならびにその方法を実施するためのキットを提供することを目的とする。検体中の2種以上の癌抑制遺伝子または癌関連遺伝子、特に、11遺伝子よりなる遺伝子群から2種以上の遺伝子を選択し、その選択した遺伝子の発現レベルまたは遺伝子発現調節の状態を調べる。具体的には遺伝子産物を定量し、その定量結果に基づいて当該遺伝子群の発現プロファイルを作成するか、あるいは発現の調節をメチル化頻度の検出により調べることに基づいて高感度・高精度な早期検出・診断を行う。MALTリンパ腫診断のための、また治療を要する病型に進展する可能性を評価するためのデータ、さらに予後不良病型への進展を早期検出するデータを得ることができる。
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