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1. WO2007145306 - ELEMENT HAVING LONG BLOOD-CIRCULATING TIME WHICH IS DEGRADABLE SELECTIVELY IN TUMOR TISSUE

Publication Number WO/2007/145306
Publication Date 21.12.2007
International Application No. PCT/JP2007/062078
International Filing Date 15.06.2007
IPC
A61K 47/42 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
A61K 9/127 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
A61K 45/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A61K 47/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen
10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols ; Poloxamers; PEG/POE alkyl ethers
A61K 47/24 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
24containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
A61K 47/34 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
CPC
A61K 47/62
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
A61K 47/6911
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
69the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
6905the form being a colloid or an emulsion
6911the form being a liposome
A61K 9/1272
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
1271Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
1272with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
A61P 1/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
Applicants
  • 国立大学法人北海道大学 NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY [JP]/[JP] (AllExceptUS)
  • 国立大学法人筑波大学 UNIVERSITY OF TSUKUBA [JP]/[JP] (AllExceptUS)
  • 秋田 英万 AKITA, Hidetaka (UsOnly)
  • 畠山 浩人 HATAKEYAMA, Hiroto (UsOnly)
  • 長崎 幸夫 NAGASAKI, Yukio [JP]/[JP] (UsOnly)
  • 大石 基 OISHI, Motoi [JP]/[JP] (UsOnly)
  • 菊池 寛 KIKUCHI, Hiroshi (UsOnly)
  • 小林 英夫 KOBAYASHI, Hideo (UsOnly)
  • 原島 秀吉 HARASHIMA, Hideyoshi (UsOnly)
Inventors
  • 秋田 英万 AKITA, Hidetaka
  • 畠山 浩人 HATAKEYAMA, Hiroto
  • 長崎 幸夫 NAGASAKI, Yukio
  • 大石 基 OISHI, Motoi
  • 菊池 寛 KIKUCHI, Hiroshi
  • 小林 英夫 KOBAYASHI, Hideo
  • 原島 秀吉 HARASHIMA, Hideyoshi
Agents
  • 特許業務法人特許事務所サイクス SIKs & Co.
Priority Data
2006-16552515.06.2006JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) ELEMENT HAVING LONG BLOOD-CIRCULATING TIME WHICH IS DEGRADABLE SELECTIVELY IN TUMOR TISSUE
(FR) ÉLÉMENT À TEMPS DE CIRCULATION SANGUINE PROLONGÉ SÉLECTIVEMENT DÉGRADABLE DANS UN TISSU TUMORAL
(JA) 腫瘍組織で選択的に分解性を示す血中滞留性素子
Abstract
(EN)
A lipid membrane structure comprising: (1) a phospholipid derivative having a residue derived from an alcohol compound, a residue derived from a phospholipid, and a peptide present between the two residues; and (2) a phospholipid derivative which is the same as the above-mentioned phospholipid derivative, except that the peptide is not contained (provided that: (a) the alcohol compound is polyalkylene glycol or the like; (b) the phospholipid is phosphatidylethanolamine, phosphatidylcholine, phosphatidylserine or the like; and (c) the peptide comprises a substrate peptide which can act as a substrate for a matrix metalloproteinase). The lipid membrane structure may be in the form of a liposome carrying an anti-cancer agent therein.
(FR)
La présente invention concerne une structure de membrane lipidique contenant : (1) un dérivé de phospholipide comportant un résidu dérivé d'un composé alcoolique, un résidu dérivé d'un phospholipide, et un peptide présent entre les deux résidus; et (2) un dérivé de phospholipide qui est similaire au dérivé de phospholipide précité, si ce n'est que le peptide n'y est pas présent (à la condition que : (a) le composé alcoolique soit du polyalkylène glycol ou un composé analogue; (b) le phospholipide soit de la phosphatidyléthanolamine, de la phosphatidylcholine, de la phosphatidylsérine ou des composés analogues; et (c) le peptide contienne un substrat peptidique qui peut servir de substrat à une métalloprotéinase matricielle). La structure de membrane lipidique peut être sous la forme d'un liposome contenant un agent anti-cancéreux.
(JA)
 アルコール化合物の残基とリン脂質類の残基とを含み、該アルコール化合物の残基とリン脂質の残基との間にペプチドを含むリン脂質誘導体(1)、及び該ペプチドの介在のない上記リン脂質誘導体(2)を含む脂質膜構造体(ただし(a)該アルコール化合物はポリアルキレングリコール類などのアルコール化合物であり、(b)該リン脂質はホスファチジルエタノールアミン類、ホスファリジルコリン類、又はホスファチジルセリン類などのリン脂質であり、及び(c)該ペプチドはマトリックスメタロプロテアーゼの基質となりうる基質ペプチドを含むペプチドである)であって、抗腫瘍剤を担持した例えばリポソーム形態である脂質膜構造体。
Also published as
Latest bibliographic data on file with the International Bureau