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1. WO2007144894 - HYDROCOLLOID CARRIER BEADS WITH INERT FILLER MATERIAL

Publication Number WO/2007/144894
Publication Date 21.12.2007
International Application No. PCT/IL2007/000733
International Filing Date 17.06.2007
IPC
A61K 9/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
16Agglomerates; Granulates; Microbeadlets
CPC
A61K 9/1611
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1605Excipients; Inactive ingredients
1611Inorganic compounds
A61K 9/1652
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1605Excipients; Inactive ingredients
1629Organic macromolecular compounds
1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
A61K 9/1694
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1682Processes
1694resulting in granules or microspheres of the matrix type containing more than 5% of excipient
Applicants
  • YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM [IL]/[IL] (AllExceptUS)
  • NUSSINOVITCH, Amos [IL]/[IL] (UsOnly)
  • GAL, Avi [IL]/[IL] (UsOnly)
Inventors
  • NUSSINOVITCH, Amos
  • GAL, Avi
Agents
  • WEBB, Cynthia
Priority Data
60/813,69115.06.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HYDROCOLLOID CARRIER BEADS WITH INERT FILLER MATERIAL
(FR) BILLES DE SUPPORT D'HYDROCOLLOÏDES COMPORTANT UN MATÉRIAU DE CHARGE INERTE
Abstract
(EN)
This invention discloses carrier beads comprising a hydrocolloid polymer comprising at least one inert filler material, wherein the at least one filler material provides improved properties including increased mechanical strength and/or reduced porosity relative to a bead without said at least one filler. The beads are useful per se or for delivery of active agents. Methods for preparation of the beads and the uses thereof are described particularly for controlling the rate of release an active agent from said bead.
(FR)
La présente invention concerne des billes de support qui contiennent un polymère hydrocolloïdal comportant au moins un matériau de charge inerte, ledit ou lesdits matériaux de charge conférant des propriétés améliorées y compris une résistance mécanique accrue et/ou une porosité réduite par rapport à une bille ne contenant pas ladite ou lesdites charges. Les billes se révèlent utiles de par leur nature ou pour la libération de principes actifs. L'invention concerne également des procédés de préparation des billes et leurs utilisations, en particulier pour la régulation de la vitesse de libération d'un principe actif à partir desdites billes.
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