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1. WO2007144685 - CD4 MIMIC PEPTIDES AND THEIR USES

Publication Number WO/2007/144685
Publication Date 21.12.2007
International Application No. PCT/IB2006/002332
International Filing Date 13.06.2006
IPC
C07K 14/705 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
A61K 38/17 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
G01N 33/68 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
CPC
A61P 31/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
18for HIV
C07K 14/70514
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
70503Immunoglobulin superfamily
70514CD4
Applicants
  • COMMISSARIAT A L'ENERGIE ATOMIQUE [FR]/[FR] (AllExceptUS)
  • SAUVAGE-VITA, Mireille [FR]/[FR] (UsOnly)
  • VITA, Fabio [FR]/[FR] (UsOnly)
  • VITA, Elena [FR]/[FR] (UsOnly)
  • MARTIN, Loïc [FR]/[FR] (UsOnly)
  • STRICHER, François [FR]/[FR] (UsOnly)
  • DESCOURS, Anne [FR]/[FR] (UsOnly)
  • MORELLATO, Laurence [FR]/[FR] (UsOnly)
Inventors
  • MARTIN, Loïc
  • STRICHER, François
  • DESCOURS, Anne
  • MORELLATO, Laurence
  • VITA, Claudio
Agents
  • CABINET, ORES
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CD4 MIMIC PEPTIDES AND THEIR USES
(FR) PEPTIDES MIMÉTIQUES DU CD4 ET UTILISATIONS DE CEUX-CI
Abstract
(EN)
An isolated peptide comprising the sequence (I): TPA-Asn-Leu-His- Phe-Cys-Gln-Leu-Xaaa-Cys-Lys-Ser-Leu-Gly-Leu-Leu-Gly-Axg-Cys-Xaab-Xaac- Xaad-Xaae-Cys-Ala-Cys-Val-NH2, wherein: TPA represents thiopropionic acid; Xaaa represents Arg, Lys; Xaab represents Ala, Arg; Xaac represents a D-amino acid; Xaad represents Thr, Ser, Asn; Xaae represents phenylalanine or a phenylalanine derivative having the structure (II), where A is absent or represents S, O, NH or CH2, B is absent or represents a C1 to C6 branched or straight-chain alkyl, and R represents a C3 to C6 alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, cycloalkenyl, cycloheterocyloalkenyl, aryl, or heteroaryl, and the use of the peptide for manufacturing anti-HIV therapeutic or vaccine compositions are disclosed herein.
(FR)
L'invention concerne un peptide isolé comprenant la séquence (I) : TPA-Asn-Leu-His-Phe-Cys-Gln-Leu-Xaaa-Cys-Lys-Ser-Leu-Gly-Leu-Leu-Gly-Axg-Cys-Xaab-Xaac-Xaad-Xaae-Cys-Ala-Cys-Val-NH2, dans laquelle : TPA représente l'acide thiopropionique ; Xaaa représente Arg, Lys ; Xaab représente Ala, Arg ; Xaac représente un acide aminé D ; Xaad représente Thr, Ser, Asn ; Xaae représente la phénylalanine ou un dérivé de la phénylalanine ayant la structure (II), où A est absent ou représente S, O, NH ou CH2, B est absent ou représente un alkyle en C1 à C6 à chaîne linéaire ou ramifiée et R représente un alkyle, hétéroalkyle, cycloalkyle, hétérocycloalkyle, cycloalcényle, hétérocycloalcényle, aryle ou hétéroaryle en C3 à C6 ; et l'utilisation du peptide pour fabriquer des compositions thérapeutiques ou de vaccin anti-VIH.
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