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1. WO2007144128 - PYRROLIDINE COMPOUNDS AS RENIN INHIBITORS

Publication Number WO/2007/144128
Publication Date 21.12.2007
International Application No. PCT/EP2007/005130
International Filing Date 11.06.2007
IPC
C07D 207/09 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
04having no double bonds between ring members or between ring members and non-ring members
08with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
09Radicals substituted by nitrogen atoms not forming part of a nitro radical
C07D 403/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 405/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
A61P 9/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
12Antihypertensives
A61K 31/40 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
CPC
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
A61P 25/22
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
22Anxiolytics
A61P 25/24
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
24Antidepressants
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 27/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27Drugs for disorders of the senses
02Ophthalmic agents
A61P 27/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27Drugs for disorders of the senses
02Ophthalmic agents
06Antiglaucoma agents or miotics
Applicants
  • NOVARTIS AG [CH]/[CH] (AllExceptUS)
  • MAIBAUM, Juergen, Klaus [DE]/[DE] (UsOnly)
  • LORTHIOIS, Edwige, Liliane, Jeanne [FR]/[FR] (UsOnly)
  • BUEHLMAYER, Peter [CH]/[CH] (UsOnly)
Inventors
  • MAIBAUM, Juergen, Klaus
  • LORTHIOIS, Edwige, Liliane, Jeanne
  • BUEHLMAYER, Peter
Agents
  • DIETEL, Anja
Priority Data
0611697.413.06.2006GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PYRROLIDINE COMPOUNDS AS RENIN INHIBITORS
(FR) COMPOSÉS ORGANIQUES
Abstract
(EN)
Novel 3,4-di-, 3,3,4-di-, 3,4.4,-tri- and 3,3,4,4-tetra-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (= disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula (I) wherein the substituents are as described in the specification.
(FR)
L'invention concerne de nouveaux composés de pyrrolidine 3,4-di-, 3,3,4-di-, 3,4,4-tri- et 3,3,4,4-tétra-substitués, ces composés étant destinés à être utilisés dans le diagnostic et le traitement thérapeutique d'un animal à sang chaud, notamment pour le traitement d'une maladie (= trouble) qui dépend d'une activité inappropriée de la rénine ; l'utilisation d'un composé de cette classe dans la préparation d'une formulation pharmaceutique pour le traitement d'une maladie qui dépend d'une activité inappropriée de la rénine ; l'utilisation d'un composé de cette classe dans le traitement d'une maladie qui dépend d'une activité inappropriée de la rénine ; des formulations pharmaceutiques comprenant un composé de pyrrolidine substitué précité, et/ou un procédé de traitement comprenant l'administration d'un composé de pyrrolidine substitué précité, un procédé de fabrication desdits composés de pyrrolidine substitués, et de nouveaux intermédiaires et étapes partielles pour leur synthèse. Les composés de pyrrolidine substitués sont notamment représentés par la formule (I) dans laquelle les substituants sont tels que définis dans la description.
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