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1. WO2007143895 - SUPERSATURATED SOLUTION OF GEMCITABINE HYDROCHLORIDE AND PREPRARATION METHOD THEREOF

Publication Number WO/2007/143895
Publication Date 21.12.2007
International Application No. PCT/CN2007/001604
International Filing Date 17.05.2007
IPC
A61K 31/7068 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706containing six-membered rings with nitrogen as a ring hetero atom
7064containing condensed or non-condensed pyrimidines
7068having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
A61K 9/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
08Solutions
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 31/7068
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706containing six-membered rings with nitrogen as a ring hetero atom
7064containing condensed or non-condensed pyrimidines
7068having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
A61K 9/0019
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • 齐鲁制药{海南}有限公司 QILU PHARMACEUTICAL (HAINAN) CO., LTD. [CN]/[CN] (AllExceptUS)
  • 韩作宏 HAN, Zuohong [CN]/[CN] (UsOnly)
  • 杨清敏 YANG, Qingmin [CN]/[CN] (UsOnly)
  • 刘宝明 LIU, Baoming [CN]/[CN] (UsOnly)
  • 张桂婷 ZHANG, Guiting [CN]/[CN] (UsOnly)
  • 张明会 ZHANG, Minghui [CN]/[CN] (UsOnly)
  • 王晶翼 WANG, Jingyi [CN]/[CN] (UsOnly)
Inventors
  • 韩作宏 HAN, Zuohong
  • 杨清敏 YANG, Qingmin
  • 刘宝明 LIU, Baoming
  • 张桂婷 ZHANG, Guiting
  • 张明会 ZHANG, Minghui
  • 王晶翼 WANG, Jingyi
Agents
  • 中国国际贸易促进委员会专利商标事务所 CCPIT PATENT AND TRADEMARK LAW OFFICE
Priority Data
200610044675.112.06.2006CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) SUPERSATURATED SOLUTION OF GEMCITABINE HYDROCHLORIDE AND PREPRARATION METHOD THEREOF
(FR) SOLUTION SUPERSATURÉE DE CHLORHYDRATE DE GEMCITABINE ET SON PROCÉDÉ DE PRÉPARATION
(ZH) 盐酸吉西他滨稳定的过饱和溶液及其制备方法
Abstract
(EN)
A stable supersaturated solution of gemcitabine hydrochloride, which is prepared by dissolving completely gemcitabine hydrochloride in a medium by heating it at pH 4-8 to give a supersaturated solution of gemcitabine having a concentrate of 15-45g/L.
(FR)
La présente invention concerne une solution supersaturée et stable de chlorhydrate de gemcitabine, préparée en dissolvant complètement du chlorhydrate de gemcitabine par un chauffage et à un pH compris entre 4 et 8, afin de produire une solution supersaturée de gemcitabine ayant une concentration de 15 à 45 g/L.
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