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1. WO2007143745 - SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS

Publication Number WO/2007/143745
Publication Date 13.12.2007
International Application No. PCT/US2007/070803
International Filing Date 08.06.2007
IPC
C07D 295/16 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
295Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
16acylated on ring nitrogen atoms
C07D 211/72 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
68having one double bond between ring members or between a ring member and a non-ring member
72with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
C07D 225/02 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
225Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
02not condensed with other rings
C07D 233/96 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
233Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
96having three double bonds between ring members or between ring members and non-ring members
C07D 207/273 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
18having one double bond between ring members or between a ring member and a non-ring member
22with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
24Oxygen or sulfur atoms
262-Pyrrolidones
273with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
C07D 295/185 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
295Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
16acylated on ring nitrogen atoms
18by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
182Radicals derived from carboxylic acids
185from aliphatic carboxylic acids
CPC
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 11/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
02Nasal agents, e.g. decongestants
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 11/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
08Bronchodilators
A61P 11/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
14Antitussive agents
Applicants
  • ICOS CORPORATION [US]/[US] (AllExceptUS)
  • DUDLER, Thomas [CH]/[US] (UsOnly)
  • FAROUZ, Francine [FR]/[US] (UsOnly)
  • FOWLER, Kerry [US]/[US] (UsOnly)
  • HAWTHORN, Nataly [US]/[US] (UsOnly)
  • HUANG, Danwen [US]/[US] (UsOnly)
  • JUDKINS, Angela [US]/[NA] (UsOnly)
  • KIM, Musong [US]/[US] (UsOnly)
  • ODINGO, Joshua [US]/[US] (UsOnly)
  • OLIVER, Amy [US]/[US] (UsOnly)
  • REED, Mark [GB]/[US] (UsOnly)
  • RUAN, Fuqiang [US]/[US] (UsOnly)
  • THORSETT, Eugene [US]/[US] (UsOnly)
Inventors
  • DUDLER, Thomas
  • FAROUZ, Francine
  • FOWLER, Kerry
  • HAWTHORN, Nataly
  • HUANG, Danwen
  • JUDKINS, Angela
  • KIM, Musong
  • ODINGO, Joshua
  • OLIVER, Amy
  • REED, Mark
  • RUAN, Fuqiang
  • THORSETT, Eugene
Agents
  • HOPKINS, Mark H.
Priority Data
60/812,39809.06.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS
(FR) ACIDES PHÉNYLACÉTIQUES SUBSTITUÉS UTILISÉS EN TANT QU'ANTAGONISTES DE DP-2
Abstract
(EN)
Substituted phenyl acetic acid compounds of formula (I), pharmaceutical compositions, methods for their preparation and methods are provided that are useful in the treatment and prevention of disorders or conditions responsive to DP 2 receptor modulation, in particular, inflammatory and immune related disorders and conditions, such as asthma, allergic rhinitis and atopic dermatitis.
(FR)
La présente invention concerne des composés d'acide phénylacétique substitués répondant à la formule (I), des compositions pharmaceutiques, des procédés pour leur préparation et des procédés qui se révèlent utiles pour le traitement et la prévention de troubles ou de pathologies sensibles à une modulation des récepteurs de DP-2, en particulier, des troubles et des pathologies inflammatoires et immunitaires, tels que l'asthme, la rhinite allergique et la dermatite atopique.
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