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1. WO2007143152 - PREPARATION OF (S)-PREGABALIN-NITRILE

Publication Number WO/2007/143152
Publication Date 13.12.2007
International Application No. PCT/US2007/013043
International Filing Date 31.05.2007
IPC
C07C 227/30 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
227Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
30Preparation of optical isomers
C07C 253/30 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
253Preparation of carboxylic acid nitriles
30by reactions not involving the formation of cyano groups
C07C 229/08 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
229Compounds containing amino and carboxyl groups bound to the same carbon skeleton
02having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
04the carbon skeleton being acyclic and saturated
06having only one amino and one carboxyl group bound to the carbon skeleton
08the nitrogen atom of the amino group being further bound to hydrogen atoms
C07C 255/19 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
255Carboxylic acid nitriles
01having cyano groups bound to acyclic carbon atoms
19containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
CPC
C07B 2200/07
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200Indexing scheme relating to specific properties of organic compounds
07Optical isomers
C07C 227/34
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
227Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
30Preparation of optical isomers
34by separation of optical isomers
C07C 253/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
253Preparation of carboxylic acid nitriles
30by reactions not involving the formation of cyano groups
Applicants
  • TEVA PHARMACEUTICAL INDUSTRIES LTD. [IL]/[IL] (AE, AG, AL, AM, AT, AU, AZ, BA, BE, BF, BG, BH, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SV, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
  • TEVA PHARMACEUTICALS USA, INC. [US]/[US] (BB)
  • HEDVATI, Lilach [IL]/[IL] (UsOnly)
  • FISHMAN, Ayelet [IL]/[IL] (UsOnly)
Inventors
  • HEDVATI, Lilach
  • FISHMAN, Ayelet
Agents
  • BIRDE, Patrick, J.
Priority Data
60/809,97831.05.2006US
60/815,61120.06.2006US
60/831,59017.07.2006US
60/831,59117.07.2006US
60/836,73009.08.2006US
60/836,73109.08.2006US
60/860,36020.11.2006US
60/879,87010.01.2007US
60/919,20120.03.2007US
60/926,05923.04.2007US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PREPARATION OF (S)-PREGABALIN-NITRILE
(FR) PRÉPARATION DE (S)-PRÉGABALINE NITRILE
Abstract
(EN)
Provided are processes for the preparation of (3S)-cyano-5-methylhexanoic acid, an intermediate in the synthesis of (S)-pregabalin.
(FR)
La présente invention concerne des procédés pour la préparation d'acide (3S)-cyano-5-méthylhexanoïque, un intermédiaire de synthèse de la (S)-prégabaline.
Also published as
Latest bibliographic data on file with the International Bureau